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Title: Metabolic molecular markers of the tidal clock in the marine crustacean Eurydice pulchra
Authors: O'Neill, J. S.
Lee, Kate D.
Zhang, Lin
Feeney, K.
Webster, S. G.
Blades, Matthew James
Kyriacou, Charalambos P.
Hastings, M. H.
Wilcockson, D. C.
First Published: 20-Apr-2015
Publisher: Elsevier (Cell Press)
Citation: Current Biology , 2015, 25 (8), pp. R326-R327
Abstract: In contrast to the well mapped molecular orchestration of circadian timekeeping in terrestrial organisms, the mechanisms that direct tidal and lunar rhythms in marine species are entirely unknown. Using a combination of biochemical and molecular approaches we have identified a series of metabolic markers of the tidal clock of the intertidal isopod Eurydice pulchra. Specifically, we show that the overoxidation of peroxiredoxin (PRX), a conserved marker of circadian timekeeping in terrestrial eukaryotes [1], follows a circatidal (approximately 12.4 hours) pattern in E. pulchra, in register with the tidal pattern of swimming. In parallel, we show that mitochondrially encoded genes are expressed with a circatidal rhythm. Together, these findings demonstrate that PRX overoxidation rhythms are not intrinsically circadian; rather they appear to resonate with the dominant metabolic cycle of an organism, regardless of its frequency. Moreover, they provide the first molecular leads for dissecting the tidal clockwork.
DOI Link: 10.1016/j.cub.2015.02.052
ISSN: 0960-9822
eISSN: 1879-0445
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015 Elsevier Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License ( ), which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Genetics

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