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|Title:||Metabolic molecular markers of the tidal clock in the marine crustacean Eurydice pulchra|
|Authors:||O'Neill, J. S.|
Lee, Kate D.
Webster, S. G.
Blades, Matthew James
Kyriacou, Charalambos P.
Hastings, M. H.
Wilcockson, D. C.
|Publisher:||Elsevier (Cell Press)|
|Citation:||Current Biology , 2015, 25 (8), pp. R326-R327|
|Abstract:||In contrast to the well mapped molecular orchestration of circadian timekeeping in terrestrial organisms, the mechanisms that direct tidal and lunar rhythms in marine species are entirely unknown. Using a combination of biochemical and molecular approaches we have identified a series of metabolic markers of the tidal clock of the intertidal isopod Eurydice pulchra. Specifically, we show that the overoxidation of peroxiredoxin (PRX), a conserved marker of circadian timekeeping in terrestrial eukaryotes , follows a circatidal (approximately 12.4 hours) pattern in E. pulchra, in register with the tidal pattern of swimming. In parallel, we show that mitochondrially encoded genes are expressed with a circatidal rhythm. Together, these findings demonstrate that PRX overoxidation rhythms are not intrinsically circadian; rather they appear to resonate with the dominant metabolic cycle of an organism, regardless of its frequency. Moreover, they provide the first molecular leads for dissecting the tidal clockwork.|
|Rights:||Copyright © 2015 Elsevier Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/ ), which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.|
|Appears in Collections:||Published Articles, Dept. of Genetics|
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