Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36797
Title: The impact of eliminating age inequalities in stage at diagnosis on breast cancer survival for older women
Authors: Rutherford, Mark J.
Abel, G. A.
Greenberg, D. C.
Lambert, Paul C.
Lyratzopoulos, G.
First Published: 3-Mar-2015
Publisher: Cancer Research UK, Nature Publishing Group
Citation: British Journal of Cancer , 2015, 112 Suppl 1, pp. S124-S128
Abstract: BACKGROUND: Older women with breast cancer have poorer relative survival outcomes, but whether achieving earlier stage at diagnosis would translate to substantial reductions in mortality is uncertain. METHODS: We analysed data on East of England women with breast cancer (2006-2010) aged 70+ years. We estimated survival for different stage-deprivation-age group strata using both the observed and a hypothetical stage distribution (assuming that all women aged 75+ years acquired the stage distribution of those aged 70-74 years). We subsequently estimated deaths that could be postponed beyond 5 years from diagnosis if women aged 75+ years had the hypothetical stage distribution. We projected findings to the English population using appropriate age and socioeconomic group weights. RESULTS: For a typically sized annual cohort in the East of England, 27 deaths in women with breast cancer aged 75+ years can be postponed within 5 years from diagnosis if their stage distribution matched that of the women aged 70-74 years (4.8% of all 566 deaths within 5 years post diagnosis in this population). Under assumptions, we estimate that the respective number for England would be 280 deaths (5.0% of all deaths within 5 years post diagnosis in this population). CONCLUSIONS: The findings support ongoing development of targeted campaigns aimed at encouraging prompt presentation in older women.
DOI Link: 10.1038/bjc.2015.51
ISSN: 0007-0920
eISSN: 1532-1827
Links: http://www.nature.com/bjc/journal/v112/n1s/full/bjc201551a.html
http://hdl.handle.net/2381/36797
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2015. Licensee: CRUK. This work is licensed under the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Health Sciences

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