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Title: Disruption of medial prefrontal synchrony in the subchronic phencyclidine model of schizophrenia in rats
Authors: Young, Andrew M. J.
Stubbendorff, C.
Valencia, M.
Gerdjikov, T. V.
First Published: 24-Dec-2014
Publisher: Elsevier for Pergamon
Citation: Neuroscience, 2015, 287, pp. 157-163
Abstract: Subchronic treatment with the N-methyl-D-aspartate (NMDA) antagonist phencyclidine (PCP) produces behavioral abnormalities in rodents which are considered a reliable pharmacological model of neurocognitive deficits in schizophrenia. Alterations in prefrontal neuronal firing after acute PCP administration have been observed, however enduring changes in prefrontal activity after subchronic PCP treatment have not been studied. To address this we have recorded cortical oscillations and unit responses in putative cortical pyramidal cells in subchronic PCP-treated rats (2mg/kg twice daily for 7 days) under urethane anesthesia. We found that this regimen reduced theta oscillations in the medial prefrontal cortex. It further produced abnormal cortical synchronization in putative cortical pyramidal cells. These alterations in prefrontal cortex functioning may contribute to cognitive deficits seen in subchronic NMDA antagonist pre-treated animals in prefrontal-dependent tasks.
DOI Link: 10.1016/j.neuroscience.2014.12.014
ISSN: 0306-4522
eISSN: 1873-7544
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 Published by Elsevier Ltd. Under a Creative Commons license ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Neuroscience, Psychology and Behaviour

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