Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36825
Title: LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression
Authors: Mura, M.
Hopkins, T. G.
Michael, T.
Abd-Latip, N.
Weir, J.
Aboagye, E.
Mauri, F.
Jameson, C.
Sturge, J.
Gabra, H.
Bushell, Martin David
Willis, A. E.
Curry, E.
Blagden, S. P.
First Published: 22-Dec-2014
Publisher: Nature Publishing Group
Citation: Oncogene, 2015, 34 (39), pp. 5025-5036
Abstract: RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5'-terminal oligopyrimidine tract (TOP) mRNA translation. Here, we show that LARP1 is complexed to 3000 mRNAs enriched for cancer pathways. A prominent member of the LARP1 interactome is mTOR whose mRNA transcript is stabilized by LARP1. At a functional level, we show that LARP1 promotes cell migration, invasion, anchorage-independent growth and in vivo tumorigenesis. Furthermore, we show that LARP1 expression is elevated in epithelial cancers such as cervical and non-small cell lung cancers, where its expression correlates with disease progression and adverse prognosis, respectively. We therefore conclude that, through the post-transcriptional regulation of genes such as mTOR within cancer pathways, LARP1 contributes to cancer progression.
DOI Link: 10.1038/onc.2014.428
ISSN: 0950-9232
eISSN: 1476-5594
Links: http://www.nature.com/onc/journal/v34/n39/full/onc2014428a.html
http://hdl.handle.net/2381/36825
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015 Macmillan Publishers Limited. All rights reserved. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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