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Title: Toward male individualization with rapidly mutating y-chromosomal short tandem repeats.
Authors: Ballantyne, K. N.
Ralf, A.
Aboukhalid, R.
Achakzai, N. M.
Anjos, M. J.
Ayub, Q.
Balažic, J.
Ballantyne, J.
Ballard, D. J.
Berger, B.
Bobillo, C.
Bouabdellah, M.
Burri, H.
Capal, T.
Caratti, S.
Cárdenas, J.
Cartault, F.
Carvalho, E. F.
Carvalho, M.
Cheng, B.
Coble, M. D.
Comas, D.
Corach, D.
D'Amato, M. E.
Davison, S.
de Knijff, P.
De Ungria, M. C.
Decorte, R.
Dobosz, T.
Dupuy, B. M.
Elmrghni, S.
Gliwiński, M.
Gomes, S. C.
Grol, L.
Haas, C.
Hanson, E.
Henke, J.
Henke, L.
Herrera-Rodríguez, F.
Hill, C. R.
Holmlund, G.
Honda, K.
Immel, U. D.
Inokuchi, S.
Jobling, Mark A.
Kaddura, M.
Kim, J. S.
Kim, S. H.
Kim, W.
King, Turi Emma
Klausriegler, E.
Kling, D.
Kovačević, L.
Kovatsi, L.
Krajewski, P.
Kravchenko, S.
Larmuseau, M. H.
Lee, E. Y.
Lessig, R.
Livshits, L. A.
Marjanović, D.
Minarik, M.
Mizuno, N.
Moreira, H.
Morling, N.
Mukherjee, M.
Munier, P.
Nagaraju, J.
Neuhuber, F.
Nie, S.
Nilasitsataporn, P.
Nishi, T.
Oh, H. H.
Olofsson, J.
Onofri, V.
Palo, J. U.
Pamjav, H.
Parson, W.
Petlach, M.
Phillips, C.
Ploski, R.
Prasad, S. P.
Primorac, D.
Purnomo, G. A.
Purps, J.
Rangel-Villalobos, H.
Rębała, K.
Rerkamnuaychoke, B.
Gonzalez, D. R.
Robino, C.
Roewer, L.
Rosa, A.
Sajantila, A.
Sala, A.
Salvador, J. M.
Sanz, P.
Schmitt, C.
Sharma, A. K.
Silva, D. A.
Shin, K. J.
Sijen, T.
Sirker, M.
Siváková, D.
Skaro, V.
Solano-Matamoros, C.
Souto, L.
Stenzl, V.
Sudoyo, H.
Syndercombe-Court, D.
Tagliabracci, A.
Taylor, D.
Tillmar, A.
Tsybovsky, I. S.
Tyler-Smith, C.
van der Gaag, K. J.
Vanek, D.
Völgyi, A.
Ward, D.
Willemse, P.
Yap, E. P.
Yong, R. Y.
Pajnič, I. Z.
Kayser, M.
First Published: 14-Jul-2014
Publisher: Wiley for Human Genome Variation Society
Citation: Human Mutation, 2014, 35 (8), pp. 1021-1032
Abstract: Relevant for various areas of human genetics, Y-chromosomal short tandem repeats (Y-STRs) are commonly used for testing close paternal relationships among individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99836-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% nonunique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). Analysis of molecular variance revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 father-son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.
DOI Link: 10.1002/humu.22599
ISSN: 1059-7794
eISSN: 1098-1004
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 The Authors. **Human Mutation published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License ( ), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Genetics

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