Please use this identifier to cite or link to this item:
|Title:||A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: Study protocol|
|Authors:||Brierley, R. C. M.|
Stokes, E. A.
Mumford, A. D.
Angelini, G. D.
Murphy, Gavin James
Rogers, C. A.
Reeves, B. C.
|Publisher:||Elsevier for World Apheresis Association|
|Citation:||Transfusion And Apheresis Science, 2014, 50 (3), pp. 451-461 (11)|
|Abstract:||Thresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoperative morbidity and health service costs compared to a liberal threshold. Patients consent to take part in the study pre-operatively but are only randomised if their haemoglobin falls below 9 g/dL during their post-operative hospital stay. The primary outcome is a binary composite outcome of any serious infectious or ischaemic event in the first three months after randomisation. Many challenges have been encountered in the set-up and running of the study.|
|Rights:||Copyright © 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/ ), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.|
|Appears in Collections:||Published Articles, Dept. of Cardiovascular Sciences|
Files in This Item:
|1-s2.0-S1473050214000652-main.pdf||Published (publisher PDF)||460.46 kB||Adobe PDF||View/Open|
Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.