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Title: A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: Study protocol
Authors: Brierley, R. C. M.
Pike, K.
Miles, A.
Wordsworth, S.
Stokes, E. A.
Mumford, A. D.
Cohen, A.
Angelini, G. D.
Murphy, Gavin James
Rogers, C. A.
Reeves, B. C.
First Published: 12-Mar-2014
Publisher: Elsevier for World Apheresis Association
Citation: Transfusion And Apheresis Science, 2014, 50 (3), pp. 451-461 (11)
Abstract: Thresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoperative morbidity and health service costs compared to a liberal threshold. Patients consent to take part in the study pre-operatively but are only randomised if their haemoglobin falls below 9 g/dL during their post-operative hospital stay. The primary outcome is a binary composite outcome of any serious infectious or ischaemic event in the first three months after randomisation. Many challenges have been encountered in the set-up and running of the study.
DOI Link: 10.1016/j.transci.2014.02.020
ISSN: 1473-0502
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license ( ), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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