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Title: Nucleotide sequence of conjugative prophage Φ1207.3 (formerly Tn1207.3) carrying the mef(A)/msr(D) genes for efflux resistance to macrolides in Streptococcus pyogenes
Authors: Iannelli, F.
Santagati, M.
Santoro, F.
Oggioni, Marco Rinaldo
Stefani, S.
Pozzi, G.
First Published: 9-Dec-2014
Publisher: Frontiers Research Foundation
Citation: Frontiers in Microbiology, 2014, 5 : 687
Abstract: Genetic element Φ1207.3 (formerly Tn1207.3) is a prophage of Streptococcus pyogenes which carries the macrolide efflux resistance genes mef(A)/msr(D) and is capable of conjugal transfer among streptococci. Complete nucleotide sequence showed that Φ1207.3 is 52,491 bp in length and contained 58 open reading frames (ORFs). A manual homology-based annotation with functional prediction of the hypothetical gene product was possible only for 34 out of 58 ORFs. Φ1207.3 codes for two different C-methylation systems, several phage structural genes, a lysis cassette (composed by a holin and a peptidoglycan hydrolase), and three site-specific resolvases of the serine recombinase family.
DOI Link: 10.3389/fmicb.2014.00687
eISSN: 1664-302X
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 Iannelli, Santagati, Santoro, Oggioni, Stefani and Pozzi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) ( ). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Appears in Collections:Published Articles, Dept. of Genetics

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