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Title: Enhanced avoidance habits in obsessive-compulsive disorder
Authors: Gillan, C. M.
Morein-Zamir, S.
Urcelay, Gonzalo Pablo
Sule, A.
Voon, V.
Apergis-Schoute, A. M.
Fineberg, N. A.
Sahakian, B. J.
Robbins, T. W.
First Published: 16-Mar-2013
Publisher: Elsevier for Society of Biological Psychiatry
Citation: Biological Psychiatry, 2014, 75 (8), pp. 631-638
Abstract: BACKGROUND: Obsessive-compulsive disorder (OCD) is a psychiatric condition that typically manifests in compulsive urges to perform irrational or excessive avoidance behaviors. A recent account has suggested that compulsivity in OCD might arise from excessive stimulus-response habit formation, rendering behavior insensitive to goal value. We tested if OCD patients have a bias toward habits using a novel shock avoidance task. To explore how habits, as a putative model of compulsivity, might relate to obsessions and anxiety, we recorded measures of contingency knowledge, explicit fear, and physiological arousal. METHODS: Twenty-five OCD patients and 25 control subjects completed a shock avoidance task designed to induce habits through overtraining, which were identified using goal-devaluation. The relationship between habitual behavior, erroneous cognitions, and physiological arousal was assessed using behavior, questionnaires, subjective report, and skin conductance responses. RESULTS: A devaluation sensitivity test revealed that both groups could inhibit unnecessary behavioral responses before overtraining. Following overtraining, OCD patients showed greater avoidance habits than control subjects. Groups did not differ in conditioned arousal (skin conductance responses) at any stage. Additionally, groups did not differ in contingency knowledge or explicit ratings of shock expectancy following the habit test. Habit responses were associated with a subjective urge to respond. CONCLUSIONS: These data indicate that OCD patients have a tendency to develop excessive avoidance habits, providing support for a habit account of OCD. Future research is needed to fully characterize the causal role of physiological arousal and explicit fear in habit formation in OCD.
DOI Link: 10.1016/j.biopsych.2013.02.002
ISSN: 0006-3223
eISSN: 1873-2402
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 Society of Biological Psychiatry. Published by Elsevier Inc.Under a Creative Commons license ( )
Appears in Collections:Published Articles, Dept. of Neuroscience, Psychology and Behaviour

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