Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36883
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dc.contributor.authorPegoraro, Mirko-
dc.contributor.authorBafna, Akanksha-
dc.contributor.authorDavies, Nathaniel J.-
dc.contributor.authorShuker, D. M.-
dc.contributor.authorTauber, Eran-
dc.date.accessioned2016-02-25T13:02:46Z-
dc.date.available2016-02-25T13:02:46Z-
dc.date.issued2015-12-15-
dc.identifier.citationGenome Research, 2016, 26 (2), pp. 203-210en
dc.identifier.issn1088-9051-
dc.identifier.urihttp://genome.cshlp.org/content/26/2/203en
dc.identifier.urihttp://hdl.handle.net/2381/36883-
dc.description.abstractMany organisms monitor the annual change in day length and use this information for the timing of their seasonal response. However, the molecular mechanisms underlying photoperiodic timing are largely unknown. The wasp Nasonia vitripennis is an emerging model organism that exhibits a strong photoperiodic response: Short autumnal days experienced by females lead to the induction of developmental arrest (diapause) in their progeny, allowing winter survival of the larvae. How female Nasonia control the developmental trajectory of their offspring is unclear. Here, we took advantage of the recent discovery that DNA methylation is pervasive in Nasonia and tested its role in photoperiodism. We used reduced representation bisulfite sequencing (RRBS) to profile DNA methylation in adult female wasps subjected to different photoperiods and identified substantial differential methylation at the single base level. We also show that knocking down DNA methyltransferase 1a (Dnmt1a), Dnmt3, or blocking DNA methylation pharmacologically, largely disrupts the photoperiodic diapause response of the wasps. To our knowledge, this is the first example for a role of DNA methylation in insect photoperiodic timing.en
dc.language.isoenen
dc.publisherCold Spring Harbor Laboratory Pressen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/26672019-
dc.rightsCopyright © 2016 Pegoraro et al.; Published by Cold Spring Harbor Laboratory Press. This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.en
dc.titleDNA methylation changes induced by long and short photoperiods in Nasoniaen
dc.typeJournal Articleen
dc.identifier.doi10.1101/gr.196204.115-
dc.identifier.eissn1549-5469-
dc.identifier.piigr.196204.115-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departmentsen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Department of Geneticsen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Genome Scienceen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Neuroscience & Behaviouren
dc.dateaccepted2015-12-14-
Appears in Collections:Published Articles, Dept. of Genetics

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