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Title: Analysis of the modified Rankin Scale in randomised controlled trials of acute ischemic stroke: A systematic review
Authors: Nunn, A.
Bath, P.
Gray, Laura
First Published: 2016
Publisher: Hindawi Publishing Corporation
Citation: Stroke Research and Treatment, 2016 (Accepted, In Press)
Abstract: Background: Historically, most acute stroke clinical trials were neutral statistically, with trials typically dichotomising ordinal scales, such as the modified Rankin Scale. Studies published before 2007 have shown that preserving the ordinal nature of these scales increased statistical power. A systematic review of trials published since 2007 was conducted to re-evaluate statistical methods used and to assess whether practice has changed. Methods: A search of electronic databases identified RCTs published between Jan 2007 and July 2014 in acute ischaemic stroke using an ordinal dependency scale as the primary outcome. Findings: Forty-two RCTs were identified. The majority used a dichotomous analysis (25, 59.5%), eight (21.4%) retained the ordinal scale and nine (19.0%) used another type of analysis. Conclusions: Trials published since 2007 still favoured dichotomous analyses over ordinal. Stroke trials, where appropriate, should consider retaining the ordinal nature of dependency scales.
ISSN: 2090-8105
eISSN: 2042-0056
Embargo on file until: 1-Jan-10000
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2016. The file associated with this record is under a permanent embargo while publication is In Press in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Health Sciences

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manuscript with changes clear.docPost-review (final submitted)256.5 kBMicrosoft WordView/Open
manuscript with changes clear.pdfPost-review (final submitted)315.16 kBAdobe PDFView/Open

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