Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36934
Title: Analysis of the Modified Rankin Scale in Randomised Controlled Trials of Acute Ischaemic Stroke: A Systematic Review
Authors: Nunn, Aimie
Bath, Philip
Gray, Laura
First Published: 1-Jun-2016
Publisher: Hindawi Publishing Corporation
Citation: Stroke Research and Treatment, 2016, Article ID 9482876
Abstract: Background: Historically, most acute stroke clinical trials were neutral statistically, with trials typically dichotomising ordinal scales, such as the modified Rankin Scale. Studies published before 2007 have shown that preserving the ordinal nature of these scales increased statistical power. A systematic review of trials published since 2007 was conducted to re-evaluate statistical methods used and to assess whether practice has changed. Methods: A search of electronic databases identified RCTs published between Jan 2007 and July 2014 in acute ischaemic stroke using an ordinal dependency scale as the primary outcome. Findings: Forty-two RCTs were identified. The majority used a dichotomous analysis (25, 59.5%), eight (21.4%) retained the ordinal scale and nine (19.0%) used another type of analysis. Conclusions: Trials published since 2007 still favoured dichotomous analyses over ordinal. Stroke trials, where appropriate, should consider retaining the ordinal nature of dependency scales.
DOI Link: 10.1155/2016/9482876
ISSN: 2090-8105
eISSN: 2042-0056
Links: https://www.hindawi.com/journals/srt/2016/9482876/abs/
http://hdl.handle.net/2381/36934
Embargo on file until: 9-Dec-2016
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2016. This is an open-access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Health Sciences

Files in This Item:
File Description SizeFormat 
9482876.pdfPublished (publisher PDF)1.29 MBAdobe PDFView/Open
manuscript with changes clear.pdfPost-review (final submitted)315.16 kBAdobe PDFView/Open


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.