Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/36997
Title: Early pregnancy metabolite profiling discovers a potential biomarker for the subsequent development of gestational diabetes mellitus
Authors: de Seymour, J. V.
Conlon, C. A.
Sulek, K.
Villas Bôas, S. G.
McCowan, L. M.
Kenny, L. C.
Baker, Philip Newton
First Published: 27-Jul-2014
Publisher: Springer Milan
Citation: Acta Diabetologica , 2014, 51 (5), pp. 887-890
Abstract: Current early pregnancy screening tools to identify women at risk of developing gestational diabetes mellitus lack both specificity and sensitivity. As a result, the foetus and mother are often subjected to insult during disease progression, prior to diagnosis and treatment in later pregnancy. Metabolomics is an analytical approach, which allows for appraisal of small molecular mass compounds in a biofluid. The aim of this pilot study was to investigate the relationship between the early gestation serum metabolite profile and the subsequent development of gestational diabetes mellitus in the search for early pregnancy biomarkers and potential metabolic mechanisms. Our nested case-control study analysed maternal serum at 20 weeks' gestation, obtained from the New Zealand cohort of the Screening for Pregnancy Endpoints study. Metabolomic profiling was performed using gas chromatography coupled to mass spectrometry, and metabolites were identified using R software and an in-house mass spectral library. Statistical analysis was performed using SPSS version 21.0. Forty-eight metabolites were identified in the serum samples. Itaconic acid (P = 0.0003), with a false discovery rate of 0.012, was found to be significantly more abundant in women who subsequently developed gestational diabetes mellitus, when compared to controls with uncomplicated pregnancies. The current pilot study found that itaconic acid may have potential as a novel biomarker in early pregnancy to predict the subsequent development of gestational diabetes mellitus. However, the findings from this pilot study require validation with a larger, diverse population before translation into the clinical setting.
DOI Link: 10.1007/s00592-014-0626-7
ISSN: 0940-5429
eISSN: 1432-5233
Links: http://link.springer.com/article/10.1007%2Fs00592-014-0626-7
http://hdl.handle.net/2381/36997
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © Springer-Verlag Italia 2014. The final publication is available at Springer via http://dx.doi.org/10.1007/s00592-014-0626-7
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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