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In line with the mission of MRC and the principles by which the Unit was created, the current research activities are focused on the understanding of the mechanisms responsible for cell dysfunction and death, which are common to disease and toxic states. We study how cells, tissues and simple organisms react to different types of injury, triggered by environmental agents as well as by endogenous molecules. This integrated approach complements the scope of classical research in toxicology and it is likely to produce fundamental advances in biomedical science. Thus, the Unit's research does not address the mechanism of action of selected groups of chemicals, but generates fundamental knowledge on the pattern responses to injury within individual cells and organs. Such knowledge is essential to address emerging public health problems that may arise from exposure to toxic substances.

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