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Title: Mid-trimester maternal ADAM12 levels differ according to fetal gender in pregnancies complicated by preeclampsia
Authors: Myers, J. E.
Thomas, G.
Tuytten, R.
Van Herrewege, Y.
Djiokep, R. O.
Roberts, C. T.
Kenny, L. C.
Simpson, N. A.
North, R. A.
Baker, Philip Newton
First Published: 4-Jun-2014
Publisher: SAGE Publications (UK and US) for Society for Gynecologic Investigation
Citation: Reproductive Sciences, 2015, 22 (2), pp. 235-241
Abstract: An overrepresentation of adverse pregnancy outcomes has been observed in pregnancies associated with a male fetus. We investigated the association between fetal gender and candidate biomarkers for preeclampsia. Proteins were quantified in samples taken at 20 weeks from women recruited to the SCreening fOr Pregnancy Endpoints (SCOPE) study (preeclampsia n = 150; no preeclampsia n = 450). In contrast to placental growth factor, soluble endoglin, and insulin-like growth factor acid labile subunit, levels of metallopeptidase domain 12 (ADAM12) at 20 weeks were dependent on fetal gender in pregnancies complicated by preeclampsia, for male (n = 73) fetuses the multiples of the median (MoM; interquartile range [IQR] 1.1-1.5) was 1.3, whereas for female fetuses (n = 75) MoM was 1.1 (1.0-1.3); P < .01. Prediction of preeclampsia using ADAM12 levels was improved for pregnancies associated with a male fetus (area under receiver-operator curve [AUC] 0.73 [95% confidence interval [CI] 0.67-0.80]) than that of a female fetus (AUC 0.62 [0.55-0.70]); P = .03. The data presented here fit a contemporary hypothesis that there is a difference between the genders in response to an adverse maternal environment and suggest that an alteration in ADAM12 may reflect an altered placental response in pregnancies subsequently complicated by preeclampsia.
DOI Link: 10.1177/1933719114537713
ISSN: 1933-7191
eISSN: 1933-7205
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014, the authors. Licensee: SAGE. Reprints and permissions: Deposited on acceptance with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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