Please use this identifier to cite or link to this item:
Title: Potential targets for the treatment of preeclampsia
Authors: Oyston, C. J.
Stanley, J. L.
Baker, Philip Newton
First Published: 21-Sep-2015
Publisher: Taylor & Francis
Citation: Expert Opinion on Therapeutic Targets, 2015, 19 (11), pp. 1517-1530
Abstract: INTRODUCTION: Preeclampsia is a disorder of pregnancy, typically characterized by hypertension and proteinuria observed after the 20th week of gestation. Preeclampsia has dire consequences for both maternal and neonatal health: it is associated with 50,000 - 100,000 annual deaths globally, as well as serious fetal and neonatal morbidity and mortality, including increased risk of fetal growth restriction and still birth. Despite the severe health, social, and economic costs of preeclampsia, currently the only curative therapy is delivery of the baby and placenta, which itself carries the associated risks of premature birth. The lack of treatments for this condition is attributable to a number of causes, including but not limited to: a partial understanding of the complex pathophysiological mechanisms underlying this complex disease; an inability to sensitively predict women who will go on to develop the disease; and a paucity of robust animal models with which to test new treatments. AREAS COVERED: Recently, progress has been made in identifying potential new therapeutic targets. This review will discuss in detail the evidence supporting further investigation of these targets, which include angiogenic factors, agents that increase vasodilation, anti-inflammatory drugs, substances that reduce oxidative stress, and statins. EXPERT OPINION: New therapeutic targets have the potential to make a significant positive impact on maternal and neonatal health. It is exciting that a number of potential therapies are currently being investigated; however, it is also vital that basic research continues to identify potential mechanisms and targets, and that any potential therapy is thoroughly tested before progression to clinical trial.
DOI Link: 10.1517/14728222.2015.1088004
ISSN: 1472-8222
eISSN: 1744-7631
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2015, Taylor and Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Opinion on Therapeutic Targets on 21 September 2015, available online:
Description: The file associated with this record is under a 12-month embargo from publication in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

Files in This Item:
File Description SizeFormat 
PB Potential targets.pdfPost-review (final submitted)474.45 kBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.