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Title: Talin Dependent Mechanosensitivity of Cell Focal Adhesions
Authors: Yan, Jie
Yao, Mingxi
Goult, Benjamin T.
Sheetz, Michael P.
First Published: 4-Nov-2014
Publisher: Springer US
Citation: Cellular and Molecular Bioengineering, 2014, 8(1), pp. 151-159
Abstract: A fundamental question in mechanobiology is how mechanical stimuli are sensed by mechanosensing proteins and converted into signals that direct cells to adapt to the external environment. A key function of cell adhesion to the extracellular matrix (ECM) is to transduce mechanical forces between cells and their extracellular environment. Talin, a cytoplasmic adapter essential for integrin-mediated adhesion to the ECM, links the actin cytoskeleton to integrin at the plasma membrane. Here, we review recent progress in the understanding of talin-dependent mechanosensing revealed by stretching single talin molecules. Rapid progress in single-molecule force manipulation technologies has made it possible to directly study the impact of mechanical force on talin’s conformations and its interactions with other signaling proteins. We also provide our views on how findings from such studies may bring new insights into understanding the principles of mechanobiology on a broader scale, and how such fundamental knowledge may be harnessed for mechanopharmacology.
DOI Link: 10.1007/s12195-014-0364-5
ISSN: 1865-5025
eISSN: 1865-5033
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2014 Biomedical Engineering Society. Available under Open Access at
Appears in Collections:Published Articles, Dept. of Biochemistry

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