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|Title:||Incident Type 2 diabetes and the effect of early regression to normoglycaemia in a population with impaired glucose regulation|
|Authors:||Bodicoat, Danielle H.|
Gray, Laura J.
Davies, Melanie J.
Webb, David R.
|Publisher:||Wiley for Diabetes UK|
|Citation:||Diabet Medicine, 2016 (Early View)|
|Abstract:||AIMS: To report contemporary regression rates from impaired glucose regulation to normal glucose tolerance, identify modifiable factors associated with early regression, and establish whether it affects subsequent diabetes risk in a population-based cohort. METHODS: Participants with impaired glucose regulation (impaired fasting glucose and/or impaired glucose tolerance on a 75-g oral glucose tolerance test) at baseline in the UK-based ADDITION-Leicester study had annual Type 2 diabetes re-screens for 5 years or until diabetes diagnosis. Logistic regression models investigated modifiable risk factors for regression to normal glucose tolerance at 1 year (n=817). Cox regression models estimated subsequent diabetes risk (n=630). RESULTS: At 1 year, 54% of participants had regressed to normal glucose tolerance, and 6% had progressed to diabetes. Regression to normal glucose tolerance was associated with weight loss of 0.1-3% [adjusted odds ratio 1.81 (95% CI 1.08, 3.03) compared with maintaining or gaining weight] and a waist circumference reduction of >3cm [adjusted odds ratio 1.78 (95% CI 1.03, 3.06) compared with maintaining or increasing waist circumference]. Those with normal glucose tolerance at 1 year subsequently had lower diabetes risk than those who remained with impaired glucose regulation [adjusted hazard ratio 0.19 (95% CI 0.10, 0.37)]. CONCLUSIONS: Early regression to normal glucose tolerance was associated with reduced diabetes incidence, and might be induced by small reductions in weight or waist circumference. If confirmed in experimental research, this could be a clear and achievable target for individuals diagnosed with impaired glucose regulation. This article is protected by copyright. All rights reserved.|
|Rights:||Copyright © 2016 Diabetes UK. This is the peer reviewed version of the following article: Incident Type 2 diabetes and the effect of early regression to normoglycaemia in a population with impaired glucose regulation, Diab. Med. (2016), which has been published in final form at dx.doi.org/10.1111/dme.13091. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.|
|Description:||The file associated with this record is under a 12-month embargo from publication in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.|
|Appears in Collections:||Published Articles, Dept. of Health Sciences|
Published Articles, Dept. of Cardiovascular Sciences
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|FINAL Progression from preDM to T2DM.docx||Post-review (final submitted)||128.89 kB||Unknown||View/Open|
|FINAL Progression from preDM to T2DM.pdf||Post-review (final submitted)||335.26 kB||Adobe PDF||View/Open|
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