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Title: Advanced-stage cervix cancer: rapid tumour growth rather than late diagnosis
Authors: Symonds, Raymond
Bolger, B.
Hole, D.
Mao, J. H.
Cooke, T.
First Published: 8-Aug-2000
Publisher: Cancer Research UK, Nature Publishing Group
Citation: Birtish Journal of Cancer, 2000, 83 (5), pp. 566-568
Abstract: Either diagnostic delay or tumour biology are possible factors governing the degree of spread at diagnosis of cervical cancer. To try to identify the most important parameter contributing to advanced stage, the duration of symptoms were recorded from patients scheduled for radiotherapy (n = 141) or radical hysterectomy (n = 36). In 146 cases tumour proliferation rates were evaluated following in vivo labelling with the DNA precursor BrdUrd. For symptomatic patients there was no association between duration of symptoms and stage at presentation. There was a significant trend for patients with increasing tumour stage to have more rapidly proliferating tumours with higher mean labelling index (LI) measurements (P = 0.001) and a shorter mean potential doubling time (Tpot) (P = 0.023). Socio economic deprivation may be associated with shorter Tpot values. The conclusion from this data is that stage at diagnosis is more dependent on the biological behaviour of the tumour, as expressed by proliferation rates, than delay in presentation.
DOI Link: 10.1054/bjoc.2000.1336
ISSN: 0007-0920
eISSN: 1532-1827
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2000, Cancer Research Campaign. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit
Appears in Collections:Published Articles, Dept. of Genetics

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