Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/37208
Full metadata record
DC FieldValueLanguage
dc.contributor.authorZheng, D.-
dc.contributor.authorArima, H.-
dc.contributor.authorSato, S.-
dc.contributor.authorGasparrini, A.-
dc.contributor.authorHeeley, E.-
dc.contributor.authorDelcourt, C.-
dc.contributor.authorLo, S.-
dc.contributor.authorHuang, Y.-
dc.contributor.authorWang, J.-
dc.contributor.authorStapf, C.-
dc.contributor.authorRobinson, Thompson Gordon-
dc.contributor.authorLavados, P.-
dc.contributor.authorChalmers, J.-
dc.contributor.authorAnderson, C. S.-
dc.contributor.authorINTERACT2 investigators-
dc.date.accessioned2016-04-08T10:17:46Z-
dc.date.available2016-04-08T10:17:46Z-
dc.date.issued2016-02-09-
dc.identifier.citationPLoS One, 2016, 11 (2), e0149040en
dc.identifier.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149040en
dc.identifier.urihttp://hdl.handle.net/2381/37208-
dc.description.abstractBACKGROUND: Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale. METHODS: INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150-220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI. RESULTS: Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99-1.91) for 10°C, 1.92 (1.31-2.81) for 0°C, 3.13 (1.89-5.19) for -10°C, and 5.76 (2.30-14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses. CONCLUSIONS: Exposure to low ambient temperature within several hours increases the risk of ICH. TRIAL REGISTRATION: ClinicalTrials.gov NCT00716079.en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/26859491-
dc.rightsCopyright © 2016 Zheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectBlood pressureen
dc.subjectHemorrhageen
dc.subjectComaen
dc.subjectAntiplatelet therapyen
dc.subjectMyocardial infarctionen
dc.subjectPrognosisen
dc.subjectRandomized controlled trialsen
dc.subjectTreatment guidelinesen
dc.titleLow Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Studyen
dc.typeJournal Articleen
dc.identifier.doi10.1371/journal.pone.0149040-
dc.identifier.eissn1932-6203-
dc.identifier.piiPONE-D-15-51682-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Cardiovascularen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Neuroscience & Behaviouren
dc.dateaccepted2016-01-26-
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

Files in This Item:
File Description SizeFormat 
Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study..pdfPublished (publisher PDF)1.38 MBAdobe PDFView/Open


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.