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|Title:||Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings|
|Authors:||Passmore, G. M.|
Reilly, J. M.
Keasberry, Vanessa N.
Marsh, S. J.
Dickenson, A. H.
Brown, D. A.
|Citation:||Frontiers in Molecular Neuroscience, 14 May 2012|
|Abstract:||M-channels carry slowly activating potassium currents that regulate excitability in a variety of central and peripheral neurons. Functional M-channels and their Kv7 channel correlates are expressed throughout the somatosensory nervous system where they may play an important role in controlling sensory nerve activity. Here we show that Kv7.2 immunoreactivity is expressed in the peripheral terminals of nociceptive primary afferents. Electrophysiological recordings from single afferents in vitro showed that block of M-channels by 3 μM XE991 sensitized Aδ- but not C-fibers to noxious heat stimulation and induced spontaneous, ongoing activity at 32°C in many Aδ-fibers. These observations were extended in vivo: intraplantar injection of XE991 selectively enhanced the response of deep dorsal horn (DH) neurons to peripheral mid-range mechanical and higher range thermal stimuli, consistent with a selective effect on Aδ-fiber peripheral terminals. These results demonstrate an important physiological role of M-channels in controlling nociceptive Aδ-fiber responses and provide a rationale for the nocifensive behaviors that arise following intraplantar injection of the M-channel blocker XE991.|
|Rights:||Copyright © 2012 Passmore, Reilly, Thakur, Keasberry, Marsh, Dickenson and Brown. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.|
|Appears in Collections:||Published Articles, Dept. of Cell Physiology and Pharmacology|
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