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Title: Determinants of day-night difference in blood pressure, a comparison with determinants of daytime and night-time blood pressure.
Authors: Musameh, M. D.
Nelson, C. P.
Gracey, J.
Tobin, M.
Tomaszewski, M.
Samani, Nilesh J.
First Published: 17-Mar-2016
Publisher: Nature Publishing Group
Citation: Journal of Human Hypertension, 2016 (Advance Online Publication)
Abstract: Blunted day-night difference in blood pressure (BP) is an independent cardiovascular risk factor, although there is limited information on determinants of diurnal variation in BP. We investigated determinants of day-night difference in systolic (SBP) and diastolic (DBP) BP and how these compared with determinants of daytime and night-time SBP and DBP. We analysed the association of mean daytime, mean night-time and mean day-night difference (defined as (mean daytime-mean night-time)/mean daytime) in SBP and DBP with clinical, lifestyle and biochemical parameters from 1562 adult individuals (mean age 38.6) from 509 nuclear families recruited in the GRAPHIC Study. We estimated the heritability of the various BP phenotypes. In multivariate analysis, there were significant associations of age, sex, markers of adiposity (body mass index and waist-hip ratio), plasma lipids (total and low-density lipoprotein cholesterol and triglycerides), serum uric acid, alcohol intake and current smoking status on daytime or night-time SBP and/or DBP. Of these, only age (P=4.7 × 10(-5)), total cholesterol (P=0.002), plasma triglycerides (P=0.006) and current smoking (P=3.8 × 10(-9)) associated with day-night difference in SBP, and age (P=0.001), plasma triglyceride (P=2.2 × 10(-5)) and current smoking (3.8 × 10(-4)) associated with day-night difference in DBP. 24-h, daytime and night-time SBP and DBP showed substantial heritability (ranging from 18-43%). In contrast day-night difference in SBP showed a lower heritability (13%) while heritability of day-night difference in DBP was not significant. These data suggest that specific clinical, lifestyle and biochemical factors contribute to inter-individual variation in daytime, night-time and day-night differences in SBP and DBP. Variation in day-night differences in BP is largely non-genetic.Journal of Human Hypertension advance online publication, 17 March 2016; doi:10.1038/jhh.2016.14.
DOI Link: 10.1038/jhh.2016.14
ISSN: 0950-9240
eISSN: 1476-5527
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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