Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/37393
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dc.contributor.authorBower, H.-
dc.contributor.authorAndersson, T. M.-
dc.contributor.authorBjörkholm, M.-
dc.contributor.authorDickman, P. W.-
dc.contributor.authorLambert, Paul Christopher-
dc.contributor.authorDerolf, Å. R.-
dc.date.accessioned2016-04-20T09:34:47Z-
dc.date.available2016-04-20T09:34:47Z-
dc.date.issued2016-02-05-
dc.identifier.citationBlood Cancer Journal, 2016, 6, e390en
dc.identifier.urihttp://www.nature.com/bcj/journal/v6/n2/full/bcj20163a.htmlen
dc.identifier.urihttp://hdl.handle.net/2381/37393-
dc.description.abstractWe evaluated temporal trends in survival of Swedish acute myeloid leukemia (AML) patients diagnosed between 1973 and 2011 using relative survival ratios (RSRs) and a measure called the loss in expectation of life (LEL). RSRs increased most for patients <60 years at diagnosis during the first calendar periods, but between 1997-2005 and 2006-2011 the most pronounced increase was for those aged 61-70 years at diagnosis; RSR changed from 0.16 (95% confidence interval (CI): 0.13-0.19) to 0.28 (95% CI: 0.23-0.33), respectively. The LEL for males aged 35 years at diagnosis was 41.0 (95% CI: 40.1-41.8) years in 1975 and 19.5 (95% CI: 16.4-22.5) years in 2011. For males aged 65 years, the corresponding figures were 13.8 (95% CI: 13.7-14.0) and 12.0 (95% CI: 11.3-12.8). Conditional LEL estimates suggested that patients who survive 5 years postdiagnosis have shorter remaining lifespan than the general population. The proportion of expected life lost (PELL) suggested that male 65-year-old patients lost 75% of their life expectancy in 2005 and 66% if they were diagnosed in 2011. Survival continued to increase to 2011, with larger improvements in those aged 61-70 years at diagnosis. The LEL and PELL are intuitive measures that may be useful in communicating survival statistics to patients, clinicians and health-care providers.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/26849011-
dc.rightsCopyright © 2016, the authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.titleContinued improvement in survival of acute myeloid leukemia patients: an application of the loss in expectation of lifeen
dc.typeJournal Articleen
dc.identifier.doi10.1038/bcj.2016.3-
dc.identifier.eissn2044-5385-
dc.identifier.piibcj20163-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Populationen
dc.dateaccepted2015-12-17-
Appears in Collections:Published Articles, Dept. of Health Sciences

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