Please use this identifier to cite or link to this item:
|Title:||Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea|
Lewis, P. A.
Martins, L. Miguel
Wood, N. W.
|Publisher:||Public Library of Science|
|Citation:||PLOS Genetics, 2010, 6 (12), e1001257|
|Abstract:||Cancer and neurodegeneration are often thought of as disease mechanisms at opposite ends of a spectrum; one due to enhanced resistance to cell death and the other due to premature cell death. There is now accumulating evidence to link these two disparate processes. An increasing number of genetic studies add weight to epidemiological evidence suggesting that sufferers of a neurodegenerative disorder have a reduced incidence for most cancers, but an increased risk for other cancers. Many of the genes associated with either cancer and/or neurodegeneration play a central role in cell cycle control, DNA repair, and kinase signalling. However, the links between these two families of diseases remain to be proven. In this review, we discuss recent and sometimes as yet incomplete genetic discoveries that highlight the overlap of molecular pathways implicated in cancer and neurodegeneration.|
|Rights:||Copyright © 2010 Plun-Favreau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
|Appears in Collections:||Published Articles, MRC Toxicology Unit|
Files in This Item:
|journal.pgen.1001257.pdf||Published (publisher PDF)||237.51 kB||Adobe PDF||View/Open|
Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.