Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/37418
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dc.contributor.authorPlun-Favreau, H.-
dc.contributor.authorLewis, P. A.-
dc.contributor.authorHardy, J.-
dc.contributor.authorMartins, L. Miguel-
dc.contributor.authorWood, N. W.-
dc.date.accessioned2016-04-21T09:52:56Z-
dc.date.available2016-04-21T09:52:56Z-
dc.date.issued2010-12-23-
dc.identifier.citationPLOS Genetics, 2010, 6 (12), e1001257en
dc.identifier.issn1553-7390-
dc.identifier.urihttp://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1001257en
dc.identifier.urihttp://hdl.handle.net/2381/37418-
dc.description.abstractCancer and neurodegeneration are often thought of as disease mechanisms at opposite ends of a spectrum; one due to enhanced resistance to cell death and the other due to premature cell death. There is now accumulating evidence to link these two disparate processes. An increasing number of genetic studies add weight to epidemiological evidence suggesting that sufferers of a neurodegenerative disorder have a reduced incidence for most cancers, but an increased risk for other cancers. Many of the genes associated with either cancer and/or neurodegeneration play a central role in cell cycle control, DNA repair, and kinase signalling. However, the links between these two families of diseases remain to be proven. In this review, we discuss recent and sometimes as yet incomplete genetic discoveries that highlight the overlap of molecular pathways implicated in cancer and neurodegeneration.en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rightsCopyright © 2010 Plun-Favreau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectScience & Technologyen
dc.subjectLife Sciences & Biomedicineen
dc.subjectGenetics & Heredityen
dc.subjectGENETICS & HEREDITYen
dc.subjectRECESSIVE JUVENILE PARKINSONISMen
dc.subjectGENOME-WIDE ASSOCIATIONen
dc.subjectTARGETING MITOCHONDRIAL DYSFUNCTIONen
dc.subjectAMYOTROPHIC-LATERAL-SCLEROSISen
dc.subjectCYCLIN-DEPENDENT KINASE-5en
dc.subjectACUTE MYELOID-LEUKEMIAen
dc.subjectTUMOR-SUPPRESSOR GENEen
dc.subjectBREAST-CANCERen
dc.subjectMULTIPLE-SCLEROSISen
dc.subjectCUTANEOUS MELANOMAen
dc.titleCancer and Neurodegeneration: Between the Devil and the Deep Blue Seaen
dc.typeJournal Articleen
dc.identifier.doi10.1371/journal.pgen.1001257-
dc.identifier.eissn1553-7404-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeReview;Journal-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departmentsen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Molecular & Cell Biologyen
Appears in Collections:Published Articles, MRC Toxicology Unit

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