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Title: Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
Authors: Eccles, S. A.
Aboagye, E. O.
Ali, S.
Anderson, A. S.
Armes, J.
Berditchevski, F.
Blaydes, J. P.
Brennan, K.
Brown, N. J.
Bryant, H. E.
Bundred, N. J.
Burchell, J. M.
Campbell, A. M.
Carroll, J. S.
Clarke, R. B.
Coles, C. E.
Cook, G. J.
Cox, A.
Curtin, N. J.
Dekker, L. V.
Silva, I. D. O. S. S.
Duffy, S. W.
Easton, D. F.
Eccles, D. M.
Edwards, D. R.
Edwards, J.
Evans, D.
Fenlon, D. F.
Flanagan, J. M.
Foster, C.
Gallagher, W. M.
Garcia-Closas, M.
Gee, J. M.
Gescher, A. J.
Goh, V.
Groves, A. M.
Harvey, A. J.
Harvie, M.
Hennessy, B. T.
Hiscox, S.
Holen, I.
Howell, S. J.
Howell, A.
Hubbard, G.
Hulbert-Williams, N.
Hunter, M. S.
Jasani, B.
Jones, L. J.
Key, T. J.
Kirwan, C. C.
Kong, A.
Kunkler, I. H.
Langdon, S. P.
Leach, M. O.
Mann, D. J.
Marshall, J. F.
Martin, L.
Martin, S. G.
Macdougall, J. E.
Miles, D. W.
Miller, W. R.
Morris, J. R.
Moss, S. M.
Mullan, P.
Natrajan, R.
O'Connor, J. P.
O'Connor, R.
Palmieri, C.
Pharoah, P. D.
Rakha, E. A.
Reed, E.
Robinson, S. P.
Sahai, E.
Saxton, J. M.
Schmid, P.
Smalley, M. J.
Speirs, V.
Stein, R.
Stingl, J.
Streuli, C. H.
Tutt, A. N.
Velikova, G.
Walker, Rosemary Ann
Watson, C. J.
Williams, K. J.
Young, L. S.
Thompson, A. M.
First Published: 1-Oct-2013
Publisher: BioMed Central
Citation: Breast Cancer Research, 2013, 15 (5), R92
Abstract: INTRODUCTION: Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. METHODS: More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer 'stem' cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. RESULTS: The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. CONCLUSIONS: With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years.
DOI Link: 10.1186/bcr3493
ISSN: 1465-5411
eISSN: 1465-542X
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © Eccles et al.; licensee BioMed Central Ltd. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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