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dc.contributor.authorGleadall, Andrew-
dc.contributor.authorPan, Jingzhe-
dc.contributor.authorKruft, Marc-Anton-
dc.contributor.authorKellomäki, Minna-
dc.identifier.citationActa Biomater, 2014, 10 (5), pp. 2233-2240en
dc.description.abstractThis paper presents an understanding of how initial molecular weight and initial monomer fraction affect the degradation of bioresorbable polymers in terms of the underlying hydrolysis mechanisms. A mathematical model was used to analyse the effects of initial molecular weight for various hydrolysis mechanisms including noncatalytic random scission, autocatalytic random scission, noncatalytic end scission or autocatalytic end scission. Different behaviours were identified to relate initial molecular weight to the molecular weight half-life and to the time until the onset of mass loss. The behaviours were validated by fitting the model to experimental data for molecular weight reduction and mass loss of samples with different initial molecular weights. Several publications that consider initial molecular weight were reviewed. The effect of residual monomer on degradation was also analysed, and shown to accelerate the reduction of molecular weight and mass loss. An inverse square root law relationship was found between molecular weight half-life and initial monomer fraction for autocatalytic hydrolysis. The relationship was tested by fitting the model to experimental data with various residual monomer contents.en
dc.rightsCopyright © the authors, 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License ( ), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en
dc.subjectBiodegradable polymersen
dc.subjectEnd scissionen
dc.subjectInitial molecular weighten
dc.subjectRandom scissionen
dc.subjectResidual monomeren
dc.subjectBiocompatible Materialsen
dc.subjectComputer Simulationen
dc.subjectModels, Theoreticalen
dc.subjectMolecular Weighten
dc.titleDegradation mechanisms of bioresorbable polyesters. Part 2. Effects of initial molecular weight and residual monomeren
dc.typeJournal Articleen
dc.type.subtypeJournal Article;Research Support, Non-U.S. Gov't-
pubs.organisational-group/Organisation/COLLEGE OF SCIENCE AND ENGINEERINGen
pubs.organisational-group/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Engineeringen
Appears in Collections:Published Articles, Dept. of Engineering

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