Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/37653
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dc.contributor.authorHamilton, Patrick-
dc.contributor.authorOgundare, Olumide-
dc.contributor.authorRaza, Ammar-
dc.contributor.authorPonnusamy, Arvind-
dc.contributor.authorGorton, Julie-
dc.contributor.authorAlachkar, Hana-
dc.contributor.authorChoudhury, Jamil-
dc.contributor.authorBarratt, Jonathan-
dc.contributor.authorKalra, Philip A.-
dc.date.accessioned2016-05-26T11:39:07Z-
dc.date.available2016-05-26T11:39:07Z-
dc.date.issued2015-
dc.identifier.citationCase Reports in Nephrology, 2015, Volume 2015, Article ID 269895en
dc.identifier.issn2090-6641-
dc.identifier.urihttp://www.hindawi.com/journals/crin/2015/269895/en
dc.identifier.urihttp://hdl.handle.net/2381/37653-
dc.description.abstractA 27-year-old man presented with a palpable purpuric skin rash and joint and abdominal pain in April 2010. He had acute kidney injury and his creatinine quickly deteriorated to 687 μmol/L, with associated nephrotic range proteinuria. Kidney biopsy showed crescentic Henoch-Schonlein nephritis. He was treated with intravenous cyclophosphamide and prednisolone despite which his renal function deteriorated; he required haemodialysis for a short duration and seven sessions of therapeutic plasma exchange (TPE). Renal function improved, but after discharge from hospital he suffered 2 further relapses, each with AKI, in 4 months. Cyclophosphamide was not effective and therefore Rituximab was introduced. He initially had a partial response but his renal function deteriorated despite continued therapy. TPE was the only treatment that prevented rapid renal functional deterioration. A novel long-term treatment strategy involving regular TPE every one to two weeks was initiated. This helped to slow his progression to end-stage kidney disease over a 3-year period and to prolong the need for renal replacement therapy over this time.en
dc.language.isoenen
dc.publisherHindawi Publishing Corporationen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/26613053-
dc.rightsCopyright © 2015 Patrick Hamilton et al. This is an open access article distributed under the Creative Commons Attribution License License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.titleLong-Term Therapeutic Plasma Exchange to Prevent End-Stage Kidney Disease in Adult Severe Resistant Henoch-Schonlein Purpura Nephritisen
dc.typeJournal Articleen
dc.identifier.doi10.1155/2015/269895-
dc.identifier.eissn2090-665X-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Cardiovascularen
dc.dateaccepted2015-10-13-
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation



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