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Title: Haplotype estimation for biobank scale datasets
Authors: O’Connell, Jared
Sharp, Kevin
Shrine, Nick
Wain, Louise
Hall, Ian
Tobin, Martin
Zagury, Jean-Francois
Delaneau, Olivier
Marchini, Jonathan
First Published: 6-Jun-2016
Publisher: Nature Publishing Group
Citation: Nature Genetics, 2016, 48, pp. 817–820
Abstract: The UK Biobank (UKB) has recently released genotypes on 152,328 individuals together with extensive phenotypic and lifestyle information. We present a new phasing method SHAPEIT3 that can handle such biobank scale datasets and results in switch error rates as low as ~0.3%. The method exhibits O(NlogN) scaling in sample size (N), enabling fast and accurate phasing of even larger cohorts.
DOI Link: 10.1038/ng.3583
ISSN: 1061-4036
eISSN: 1546-1718
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © The Author(s), 2016. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Health Sciences

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