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|Title:||Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer|
|Authors:||Heaney, Liam M.|
Ruszkiewicz, Dorota M.
Arthur, Kayleigh L.
Lindley, Martin R.
Thomas, C. L. Paul
Turner, Matthew A.
Reynolds, James C.
|Citation:||Bioanalysis, 2016, 8 (13), pp. 1325-1336|
|Abstract:||AIM: Breath analyses have potential to detect early signs of disease onset. Ambient ionization allows direct combination of breath gases with MS for fast, on-line analysis. Portable MS systems would facilitate field/clinic-based breath analyses. Results & methodology: Volunteers ingested peppermint oil capsules and exhaled volatile compounds were monitored over 10 h using a compact mass spectrometer. A rise and fall in exhaled menthone was observed, peaking at 60-120 min. Real-time analysis showed a gradual rise in exhaled menthone postingestion. Sensitivity was comparable to established methods, with detection in the parts per trillion range. CONCLUSION: Breath volatiles were readily analyzed on a portable mass spectrometer through a simple inlet modification. Induced changes in exhaled profiles were detectable with high sensitivity and measurable in real-time.|
|Embargo on file until:||1-Jul-2017|
|Rights:||Copyright © 2016, Future Science. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.|
|Appears in Collections:||Published Articles, Dept. of Cardiovascular Sciences|
Files in This Item:
|Heaney et al - CMS accepted manuscript.pdf||Post-review (final submitted author manuscript)||1.51 MB||Adobe PDF||View/Open|
|Heaney et al - Supplementary material.pdf||Post-review (final submitted author manuscript)||645.64 kB||Adobe PDF||View/Open|
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