Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/37842
Title: Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer
Authors: Heaney, Liam M.
Ruszkiewicz, Dorota M.
Arthur, Kayleigh L.
Hadjithekli, Andria
Aldcroft, Clive
Lindley, Martin R.
Thomas, C. L. Paul
Turner, Matthew A.
Reynolds, James C.
First Published: Jul-2016
Publisher: Future Science
Citation: Bioanalysis, 2016, 8 (13), pp. 1325-1336
Abstract: AIM: Breath analyses have potential to detect early signs of disease onset. Ambient ionization allows direct combination of breath gases with MS for fast, on-line analysis. Portable MS systems would facilitate field/clinic-based breath analyses. Results & methodology: Volunteers ingested peppermint oil capsules and exhaled volatile compounds were monitored over 10 h using a compact mass spectrometer. A rise and fall in exhaled menthone was observed, peaking at 60-120 min. Real-time analysis showed a gradual rise in exhaled menthone postingestion. Sensitivity was comparable to established methods, with detection in the parts per trillion range. CONCLUSION: Breath volatiles were readily analyzed on a portable mass spectrometer through a simple inlet modification. Induced changes in exhaled profiles were detectable with high sensitivity and measurable in real-time.
DOI Link: 10.4155/bio-2016-0045
eISSN: 1757-6199
Links: http://www.future-science.com/doi/10.4155/bio-2016-0045
http://hdl.handle.net/2381/37842
Embargo on file until: 1-Jul-2017
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2016, Future Science. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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Heaney et al - CMS accepted manuscript.pdfPost-review (final submitted author manuscript)1.51 MBAdobe PDFView/Open
Heaney et al - Supplementary material.pdfPost-review (final submitted author manuscript)645.64 kBAdobe PDFView/Open


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