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Title: TAp73 promotes anti-senescence-anabolism not proliferation
Authors: Agostini, Massimiliano
Niklison-Chirou, Maria Victoria
Catani, Maria Valeria
Knight, Richard A.
Melino, Gerry
Rufini, Alessandro
First Published: 13-Nov-2014
Publisher: Impact Journals
Citation: Aging, 2014, 6 (11), pp. 921-930
Abstract: TAp73, a member of the p53 family, has been traditionally considered a tumor suppressor gene, but a recent report has claimed that it can promote cellular proliferation. This assumption is based on biochemical evidence of activation of anabolic metabolism, with enhanced pentose phosphate shunt (PPP) and nucleotide biosynthesis. Here, while we confirm that TAp73 expression enhances anabolism, we also substantiate its role in inhibiting proliferation and promoting cell death. Hence, we would like to propose an alternative interpretation of the accumulating data linking p73 to cellular metabolism: we suggest that TAp73 promotes anabolism to counteract cellular senescence rather than to support proliferation.
DOI Link: 10.18632/aging.100701
eISSN: 1945-4589
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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