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Title: Nutrient availability links mitochondria, apoptosis, and obesity
Authors: Pintus, Francesca
Floris, Giovanni
Rufini, Alessandro
First Published: 30-Nov-2012
Publisher: Impact Journals
Citation: Aging, 2012, 4 (11), pp. 734-741
Abstract: Mitochondria are the dominant source of the cellular energy requirements through oxidative phosphorylation, but they are also central players in apoptosis. Nutrient availability may have been the main evolutionary driving force behind these opposite mitochondrial functions: production of energy to sustain life and release of apoptotic proteins to trigger cell death. Here, we explore the link between nutrients, mitochondria and apoptosis with known and potential implications for age-related decline and metabolic syndromes.
DOI Link: 10.18632/aging.100505
eISSN: 1945-4589
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2012. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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