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Title: Reviewing the epigenetics of schizophrenia
Authors: Cromby, John J.
Chung, Emma
Papadopoulos, Dimitris
Talbot, Chris
First Published: 25-Aug-2016
Publisher: Taylor & Francis
Citation: Journal of Mental Health, 2016
Abstract: Background: Epigenetic research in mental health has grown exponentially during the last decade and holds what some claim are ‘revolutionary’ potentials for the development of new interdisciplinary models of mental ill health. Schizophrenia is the most appropriate diagnosis against which to assess progress in this regard. Method: Papers on epigenetics and schizophrenia identified in a systematic literature search are subject to a conceptually-driven narrative review that assesses the relations between schizophrenia and epigenetics; considers some issues associated with empirical studies; and thereby identifies key assumptions guiding this research. Findings: The revolutionary potentials of epigenetics are thus far not being realised due to various influences including a preponderance of hypotheses that begin from a primarily biological question; the ‘flattening’ of environmental influences and their effective reduction to their molecular consequences; and a frequent reliance upon animal studies that effectively preclude some important influences already established as relevant to this diagnosis. Conclusion: Epigenetic research in schizophrenia (and mental health generally) could benefit from being more thoroughly interdisciplinary, from testing hypotheses that foreground social as well as biological influences, and from reconsidering its reliance upon psychiatric diagnoses.
DOI Link: 10.1080/09638237.2016.1207229
ISSN: 0963-8237
eISSN: 1360-0567
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2016 Taylor & Francis. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Description: The file associated with this record is under a 12 month embargo from publication in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, School of Management

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