Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/37999
Title: Neuro-cardiac interaction in malignant ventricular arrhythmia and sudden cardiac death
Authors: Ng, G. André
First Published: 5-Jul-2016
Publisher: Elsevier on behalf of International Society for Autonomic Neuroscience
Citation: Autonomic Neuroscience: Basic and Clinical, 2016, in press
Abstract: Sudden cardiac death as a result of lethal ventricular arrhythmias is a major cause of death in cardiac diseases such as heart failure and prior myocardial infarct. Activity of the autonomic nervous system is often abnormal where sympathetic activity is upregulated and vagal activity reduced in these conditions. The abnormal autonomic state has been shown to be a strong prognostic marker of increased mortality and propensity to lethal arrhythmias, for which there is no effective prevention. Research effort over the years has established good evidence for a causal link between autonomic disturbance and ventricular arrhythmias. However, the detailed electrophysiological mechanisms by which ventricular fibrillation occurs are still not clear and molecular processes which are modulated by autonomic nerve influences that either predispose the heart to or protect it from these arrhythmias are not fully understood. This review presents data from studies investigating the link between activity of the autonomic nervous system and ventricular arrhythmias, from seminal findings in classical studies to ongoing investigations, in the quest for a better understanding of the arrhythmogenic mechanisms underlying neurocardiac interactions with a view to the development of effective preventative and therapeutic strategies which are very much needed.
DOI Link: 10.1016/j.autneu.2016.07.001
eISSN: 1872-7484
Links: TBC
http://hdl.handle.net/2381/37999
Embargo on file until: 5-Jul-2017
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2016, International Society for Autonomic Neuroscience. Deposited with reference to the publisher’s open access archiving policy.
Description: The file associated with this record is under a 12 month embargo from publication in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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