Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/38027
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dc.contributor.authorYang, Yunlong-
dc.contributor.authorAndersson, Patrik-
dc.contributor.authorHosaka, Kayoko-
dc.contributor.authorZhang, Yin-
dc.contributor.authorCao, Renhai-
dc.contributor.authorIwamoto, Hideki-
dc.contributor.authorYang, Xiaojuan-
dc.contributor.authorNakamura, Masaki-
dc.contributor.authorWang, Jian-
dc.contributor.authorZhuang, Rujie-
dc.contributor.authorMorikawa, Hiromasa-
dc.contributor.authorXue, Yuan-
dc.contributor.authorBraun, Harald-
dc.contributor.authorBeyaert, Rudi-
dc.contributor.authorSamani, Nilesh-
dc.contributor.authorNakae, Susumu-
dc.contributor.authorHams, Emily-
dc.contributor.authorDissing, Steen-
dc.contributor.authorFallon, Padraic G.-
dc.contributor.authorLanger, Robert-
dc.contributor.authorCao, Yihai-
dc.date.accessioned2016-08-31T15:29:29Z-
dc.date.available2016-08-31T15:29:29Z-
dc.date.issued2016-05-06-
dc.identifier.citationNature Communications, 2016, 7, article number 11385en
dc.identifier.urihttp://www.nature.com/ncomms/2016/160506/ncomms11385/full/ncomms11385.htmlen
dc.identifier.urihttp://hdl.handle.net/2381/38027-
dc.description.abstractSignalling molecules and pathways that mediate crosstalk between various tumour cellular compartments in cancer metastasis remain largely unknown. We report a mechanism of the interaction between perivascular cells and tumour-associated macrophages (TAMs) in promoting metastasis through the IL-33–ST2-dependent pathway in xenograft mouse models of cancer. IL-33 is the highest upregulated gene through activation of SOX7 transcription factor in PDGF-BB-stimulated pericytes. Gain- and loss-of-function experiments validate that IL-33 promotes metastasis through recruitment of TAMs. Pharmacological inhibition of the IL-33–ST2 signalling by a soluble ST2 significantly inhibits TAMs and metastasis. Genetic deletion of host IL-33 in mice also blocks PDGF-BB-induced TAM recruitment and metastasis. These findings shed light on the role of tumour stroma in promoting metastasis and have therapeutic implications for cancer therapy.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/27150562-
dc.rightsCopyright © the authors, 2016. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.titleThe PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophagesen
dc.typeJournal Articleen
dc.identifier.doi10.1038/ncomms11385-
dc.identifier.eissn2041-1723-
dc.identifier.piincomms11385-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeJournal Article-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicineen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Cardiovascularen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Genome Scienceen
dc.dateaccepted2016-03-21-
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences



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