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Title: A Mechanistic Model for Acidic Drug Release Using Microspheres Made of PLGA 50:50
Authors: Sevim, Kevser
Pan, Jingzhe
First Published: 11-Jul-2016
Publisher: American Chemical Society
Citation: Molecular Pharmaceutics, 2016, 13 (8), pp. 2729-2735
Abstract: Polyester microspheres are extensively studied for controlled release drug delivery devices, and many models have been developed to describe drug release from the bulk polymer. However, the interaction between drugs and polymers is ignored in most of the existing mathematical models. This paper presents a mechanistic model which captures the interplay between acidic drugs and bioresorbable polyesters. The model considers the autocatalytic effect on polymer degradation arising from carboxylic acid end groups of oligomers and drug molecules. Hence, the enhancing effect of acidic drug on the rate of degradation was fully considered. On the other hand the drug release from polyester microspheres is controlled by drug diffusion from polymer matrix. The drug diffusion coefficient depends strongly on the level of degradation of the polymer. This effect is also included in the model. It is shown that the model can effectively predict experimental data in the literature for both polymer degradation and drug release. Furthermore, the model is used to design different systems of microspheres which release drugs with either a zero order profile or burst followed by zero order release profile.
DOI Link: 10.1021/acs.molpharmaceut.6b00313
ISSN: 1543-8384
eISSN: 1543-8392
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © American Chemical Society, 2016. This version of the article is distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License ( ), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Description: Following the embargo period the above license applies.
Appears in Collections:Published Articles, Dept. of Engineering

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