Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/38264
Title: The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
Authors: Ehret, G. B.
Ferreira, T.
Chasman, D. I.
Jackson, A. U.
Schmidt, E. M.
Johnson, T.
Thorleifsson, G.
Luan, J.
Donnelly, L. A.
Kanoni, S.
Petersen, A. K.
Warren, H.
Kim, Y. J.
Zhao, W.
Wu, Y.
Tayo, B. O.
Gräßler, J.
Bochud, M.
CHARGE-EchoGen Consortium
CHARGE-HF Consortium
O'Reilly, P. F.
Wilks, R.
Wellcome Trust Case Control Consortium
Absher, D.
Adair, L. S.
Amin, N.
Arking, D. E.
Axelsson, T.
Baldassarre, D.
Groves, C. J.
Balkau, B.
Bandinelli, S.
Wilsgaard, T.
Shah, S.
Barnes, M. R.
Barroso, I.
Bevan, S.
Bis, J. C.
Bjornsdottir, G.
Boehnke, M.
Boerwinkle, E.
Bonnycastle, L. L.
Gudnason, V.
Wilson, J. F.
Boomsma, D. I.
Franceschini, N.
Bornstein, S. R.
Brown, M. J.
Burnier, M.
Cabrera, C. P.
Chambers, J. C.
Chang, I. S.
Cheng, C. Y.
Chines, P. S.
Wong, T. Y.
Chung, R. H.
Gyllensten, U.
Ong, K. K.
Collins, F. S.
Connell, J. M.
Döring, A.
Dallongeville, J.
Danesh, J.
de Faire, U.
Delgado, G.
Yang, T. P.
Dominiczak, A. F.
Doney, A. S.
Drenos, F.
Paccaud, F.
Hallmans, G.
Edkins, S.
Eicher, J. D.
Elosua, R.
Enroth, S.
Erdmann, J.
Magnusson, P. K.
Eriksson, P.
Esko, T.
Evangelou, E.
Evans, A.
Palmer, C. D.
Fall, T.
Hartikainen, A. L.
Farrall, M.
Felix, J. F.
Ferrières, J.
Yao, J.
Ferrucci, L.
Fornage, M.
Forrester, T.
Strawbridge, R. J.
Hassinen, M.
Parsa, A.
Havulinna, A. S.
Hayward, C.
Hercberg, S.
Herzig, K .H.
Yengo, L.
Hicks, A. A.
Hingorani, A. D.
Hirschhorn, J. N.
Hofman, A.
Holmen, J.
Shungin, D.
Pedersen, N. L.
Holmen, O. L.
Hottenga, J. J.
Howard, P.
Zhang, W.
Hsiung, C. A.
Hunt, S. C.
Ikram, M. A.
Illig, T.
Iribarren, C.
Jensen, R. A.
Kähönen, M.
Penninx, B. W.
Hughes, M. F.
Kang, H. M.
Gigante, B.
Kathiresan, S.
Keating, B. J.
Khaw, K. T.
Kim, Y. K.
Kim, E.
Kivimaki, M.
Klopp, N.
Kolovou, G.
Perola, M.
Komulainen, P.
Montasser, M. E.
Meirelles, O.
Kooner, J. S.
Kosova, G.
Krauss, R. M.
Kuh, D.
Kutalik, Z.
Kuusisto, J.
Kvaløy, K.
Lakka, T. A.
Peters, A.
Zhao, J. H.
Lee, N. R.
Lee, I. T.
Kaakinen, M.
Lee, W. J.
Levy, D.
Li, X.
Liang, K. W.
Lin, H.
Lin, L.
Lindström, J.
Zhu, X.
Poulter, N.
Lobbens, S.
Männistö, S.
Müller, G.
Bouatia-Naji, N.
Müller-Nurasyid, M.
Mach, F.
Markus, H. S.
Marouli, E.
McCarthy, M. I.
Bovet, P.
McKenzie, C. A.
Pramstaller, P. P.
Meneton, P.
Menni, C.
Metspalu, A.
Mijatovic, V.
Kristiansson, K.
Moilanen, L.
Franco, O. H.
Kleber, M. E.
Cooper, R. S.
Psaty, B. M.
Quertermous, T.
Rao, D. C.
Rasheed, A.
Rayner, N. W.
Renström, F.
Rettig, R.
Rice, K. M.
Roberts, R.
Franco-Cereceda, A.
Mohlke, K. L.
Rose, LM
Guo, X.
Rossouw, J.
Samani, N. J.
Sanna, S.
Saramies, J.
Schunkert, H.
Sebert, S.
Sheu, W. H.
Shin, Y. A.
Saleheen, D.
Fraser, R. M.
Sim, X.
Smit, J. H.
Lyytikäinen, L. P.
Smith, A. V.
Sosa, M. X.
Spector, T. D.
Stančáková, A.
Stanton, A. V.
Stirrups, K. E.
Lee, J. Y.
Stringham, H. M.
Ganesh, S. K.
Sundstrom, J.
Swift, A. J.
Syvänen, A. C.
Fava, C.
Tai, E. S.
Tanaka, T.
Tarasov, K. V.
Teumer, A.
Salfati, E. L.
Thorsteinsdottir, U.
Tobin, M. D.
Gao, H.
Tremoli, E.
Uitterlinden, A. G.
Uusitupa, M.
Vaez, A.
Eriksson, N.
Vaidya, D.
van Duijn, C. M.
Elliott, P.
van Iperen, E. P.
Vasan, R. S.
Verwoert, G. C.
Gertow, K.
Virtamo, J.
Vitart, V.
Voight, B. F.
Vollenweider, P.
Wagner, A.
Nolte, I. M.
Gierman, H. J.
Wain, Louise V.
Wareham, N. J.
Watkins, H.
Weder, A. B.
Gianfagna, F.
Westra, H. J.
Morris, A. D.
Giulianini, F.
Willer, C. J.
Franke, L.
Hovingh, G. K.
Taylor, K. D.
Dedoussis, G.
Sever, P.
Wong, A.
Lind, L.
Rallidis, L. S.
Morrison, A. C.
Assimes, T. L.
Pihur, V.
Njølstad, I.
Schwarz, P. E.
Langenberg, C.
Snieder, H.
Caulfield, M. J.
Melander, O.
Laakso, M.
Saltevo, J.
Mulas, A.
Rauramaa, R.
Theusch, E.
Goel, A.
Tuomilehto, J.
Ingelsson, E.
Lehtimäki, T.
Hveem, K.
Palmas, W.
März, W.
Kumari, M.
Nagaraja, R.
Salomaa, V.
Chen, Y. D.
Rotter, J. I.
Goodall, A. H.
Smith, A. J.
Froguel, P.
Jarvelin, M. R.
Lakatta, E. G.
Kuulasmaa, K.
Franks, P. W.
Narisu, N.
Hamsten, A.
Wichmann, H. E.
Palmer, C. N.
Stefansson, K.
Goodarzi, M. O.
Ridker, P. M.
Folkersen, L.
Loos, R. J.
Chakravarti, A.
Deloukas, P.
Nikus, K.
Morris, A. P.
Newton-Cheh, C.
Munroe, P. B.
Witkowska, K.
Pers, T. H.
Gorski, M.
Joehanes, R.
Kim, S. K.
Lataniotis, L.
Jansen, R.
O'Donnell, C. J.
Johnson, A. D.
First Published: 12-Sep-2016
Publisher: Nature Publishing Group
Citation: Nature Genetics, 2016, 48 (10), pp. 1171-1184
Abstract: To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.
DOI Link: 10.1038/ng.3667
ISSN: 1061-4036
eISSN: 1546-1718
Links: http://www.nature.com/ng/journal/v48/n10/full/ng.3667.html
http://hdl.handle.net/2381/38264
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2016 Nature Publishing Group. Deposited with reference to the publisher’s archiving policy available on the SHERPA/RoMEO website.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

Files in This Item:
File Description SizeFormat 
01a_NG-A41405R_manuscript_finalCLEAN.pdfPost-review (final submitted author manuscript)1.3 MBAdobe PDFView/Open
01b_NG-A41405R_Fig1_final.pdfPost-review (final submitted author manuscript)3.4 MBAdobe PDFView/Open
01c_NG-A41405R_Fig2_final.pdfPost-review (final submitted author manuscript)1.55 MBAdobe PDFView/Open
02_NG-A41405R_SuppNote_finalCLEAN.pdfPost-review (final submitted author manuscript)12.15 MBAdobe PDFView/Open
03_NG-A41405R_SuppTables_final.xlsxPost-review (final submitted author manuscript)475.98 kBUnknownView/Open


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.