Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/38293
Title: Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB.
Authors: Aksenova, V.
Turoverova, L.
Khotin, M
Magnusson, K. E.
Tulchinsky, Eugene
Melino, Gerry
Pinaev, G. P.
Barlev, Nickolai
Tentler, D.
First Published: 28-Feb-2013
Publisher: Impact Journals
Citation: Oncotarget, 2013, 4 (2), pp. 362-372
Abstract: ACTN4 is an actin-binding protein that participates in cytoskeleton organisation. It resides both in the cytoplasm and nucleus and physically associates with various transcription factors. Here, we describe an effect of ACTN4 expression on transcriptional activity of the RelA/p65 subunit of NF-kB. We demonstrate that ACTN4 enhances RelA/p65-dependant expression of c-fos, MMP-3 and MMP-1 genes, but it does not affect TNC, ICAM1 and FN1 expression. Importantly, actin-binding domains of ACTN4 are not critical for the nuclear translocation and co-activation of RelA/p65- dependent transcription. Collectively, our data suggest that in the nucleus, ACTN4 functions as a selective transcriptional co-activator of RelA/p65.
DOI Link: 10.18632/oncotarget.901
eISSN: 1949-2553
Links: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=901
http://hdl.handle.net/2381/38293
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Creative Commons Attribution 3.0 License.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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