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|Title:||A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment.|
Chaplin, L. C.
Spriggs, R. V.
Dyer, M. J.
Yeomans, A. M.
Wagner, S. D.
Willis, A. E.
|Publisher:||Nature Publishing Group for Associazione Differenziamento e Morte Cellulare|
|Citation:||Cell Death and Disease (2016) 7, e2249;|
|Abstract:||We have used polysome profiling coupled to microarray analysis to examine the translatome of a panel of peripheral blood (PB) B cells isolated from 34 chronic lymphocytic leukaemia (CLL) patients. We have identified a 'ribosome-related' signature in CLL patients with mRNAs encoding for ribosomal proteins and factors that modify ribosomal RNA, e.g. DKC1 (which encodes dyskerin, a pseudouridine synthase), showing reduced polysomal association and decreased expression of the corresponding proteins. Our data suggest a general impact of dyskerin dysregulation on the translational apparatus in CLL and importantly patients with low dyskerin levels have a significantly shorter period of overall survival following treatment. Thus, translational dysregulation of dyskerin could constitute a mechanism by which the CLL PB B cells acquire an aggressive phenotype and thus have a major role in oncogenesis.|
|Rights:||This work is licensed under a Creative Commons Attribution 4.0 International License.|
|Description:||Supplementary Information accompanies this paper on Cell Death and Disease website|
|Appears in Collections:||Published Articles, Dept. of Cancer Studies and Molecular Medicine|
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