Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/38420
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGaur, V.-
dc.contributor.authorConnor, T.-
dc.contributor.authorSanigorski, A.-
dc.contributor.authorMartin, S. D.-
dc.contributor.authorBruce, C. R.-
dc.contributor.authorHenstridge, D. C.-
dc.contributor.authorBond, S. T.-
dc.contributor.authorMcEwen, K. A.-
dc.contributor.authorKerr-Bayles, L.-
dc.contributor.authorAshton, T. D.-
dc.contributor.authorFleming, C.-
dc.contributor.authorWu, M.-
dc.contributor.authorWiner, L. S. P.-
dc.contributor.authorChen, D.-
dc.contributor.authorHudson, Gregg M.-
dc.contributor.authorSchwabe, John W. R.-
dc.contributor.authorBaar, K.-
dc.contributor.authorFebbraio, M. A.-
dc.contributor.authorGregorevic, P.-
dc.contributor.authorPfeffer, F. M.-
dc.contributor.authorWalder, K. R.-
dc.contributor.authorHargreaves, M.-
dc.contributor.authorMcGee, S. L.-
dc.date.accessioned2016-11-09T12:34:43Z-
dc.date.available2016-11-09T12:34:43Z-
dc.date.issued2016-09-13-
dc.identifier.citationCell Reports, 2016, 16 (11), pp. 2802-2810 (9)en
dc.identifier.issn2211-1247-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S2211124716310518en
dc.identifier.urihttp://hdl.handle.net/2381/38420-
dc.descriptionThe accession number for the microarray dataset reported in this paper is GEO: GSE54642.en
dc.description.abstractDrugs that recapitulate aspects of the exercise adaptive response have the potential to provide better treatment for diseases associated with physical inactivity. We previously observed reduced skeletal muscle class IIa HDAC (histone deacetylase) transcriptional repressive activity during exercise. Here, we find that exercise-like adaptations are induced by skeletal muscle expression of class IIa HDAC mutants that cannot form a corepressor complex. Adaptations include increased metabolic gene expression, mitochondrial capacity, and lipid oxidation. An existing HDAC inhibitor, Scriptaid, had similar phenotypic effects through disruption of the class IIa HDAC corepressor complex. Acute Scriptaid administration to mice increased the expression of metabolic genes, which required an intact class IIa HDAC corepressor complex. Chronic Scriptaid administration increased exercise capacity, whole-body energy expenditure and lipid oxidation, and reduced fasting blood lipids and glucose. Therefore, compounds that disrupt class IIa HDAC function could be used to enhance metabolic health in chronic diseases driven by physical inactivity.en
dc.description.sponsorshipThis research was supported by the Diabetes Australia Research Trust Viertel Award and by grants from the National Health and Medical Research Council (NHMRC) of Australia (1027727) and the Deakin University Molecular and Medical Research Strategic Research Centre to S.L.M. J.W.R.S. is supported by Wellcome Trust Senior Investigator Award WT100237 and is a Royal Society Merit Award Holder. M.A.F., P.G., and S.L.M. are supported by research fellowships from the NHMRC.en
dc.language.isoenen
dc.publisherElsevier (Cell Press): OAJen
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en
dc.subjectScience & Technologyen
dc.subjectLife Sciences & Biomedicineen
dc.subjectCell Biologyen
dc.subjectHUMAN SKELETAL-MUSCLEen
dc.subjectHISTONE DEACETYLASE INHIBITORSen
dc.subjectEXERCISEen
dc.subjectREPRESSIONen
dc.subjectREVEALSen
dc.subjectSkeletal muscleen
dc.subjectHDAC4en
dc.subjectHDAC5en
dc.subjectMEF2en
dc.titleDisruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidationen
dc.typeJournal Articleen
dc.identifier.doi10.1016/j.celrep.2016.08.005-
dc.identifier.eissn2211-1247-
dc.description.statusPeer-revieweden
dc.description.versionPublisher Versionen
dc.type.subtypeArticle;Journal-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGYen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departmentsen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Molecular & Cell Biologyen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themesen
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Canceren
pubs.organisational-group/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/Themes/Molecular & Cellular Bioscienceen
dc.dateaccepted2016-07-31-
Appears in Collections:Published Articles, Dept. of Molecular and Cell Biology

Files in This Item:
File Description SizeFormat 
1-s2.0-S2211124716310518-main.pdfPublished (publisher PDF)2.87 MBAdobe PDFView/Open


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.