Please use this identifier to cite or link to this item:
Title: Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
Authors: Weldon, Carika
Behm-Ansmant, Isabelle
Hurley, Laurence H.
Burley, Glenn A.
Branlant, Christiane
Eperon, Ian C.
Dominguez, Cyril
First Published: 7-Nov-2016
Publisher: Nature Publishing Group
Citation: Nature Chemical Biology, 2017, 13, pp. 18-20
Abstract: RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.
DOI Link: 10.1038/nchembio.2228
ISSN: 1552-4450
eISSN: 1552-4469
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2016, Nature Publishing Group. Deposited with reference to the publisher’s open access archiving policy.
Appears in Collections:Published Articles, Dept. of Molecular and Cell Biology

Files in This Item:
File Description SizeFormat 
Manuscript-figures.pdfPost-review (final submitted author manuscript)1.73 MBAdobe PDFView/Open
SupplementaryResults.pdfPost-review (final submitted author manuscript)12.83 MBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.