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|Title:||Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA|
Hurley, Laurence H.
Burley, Glenn A.
Eperon, Ian C.
|Publisher:||Nature Publishing Group|
|Citation:||Nature Chemical Biology, 2017, 13, pp. 18-20|
|Abstract:||RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.|
|Rights:||Copyright © 2016, Nature Publishing Group. Deposited with reference to the publisher’s open access archiving policy.|
|Appears in Collections:||Published Articles, Dept. of Molecular and Cell Biology|
Files in This Item:
|Manuscript-figures.pdf||Post-review (final submitted author manuscript)||1.73 MB||Adobe PDF||View/Open|
|SupplementaryResults.pdf||Post-review (final submitted author manuscript)||12.83 MB||Adobe PDF||View/Open|
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