Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/38524
Title: Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
Authors: Weldon, Carika
Behm-Ansmant, Isabelle
Hurley, Laurence H.
Burley, Glenn A.
Branlant, Christiane
Eperon, Ian C.
Dominguez, Cyril
First Published: 7-Nov-2016
Publisher: Nature Publishing Group
Citation: Nature Chemical Biology, 2016, in press
Abstract: RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.
DOI Link: 10.1038/nchembio.2228
ISSN: 1552-4450
eISSN: 1552-4469
Links: http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.2228.html
http://hdl.handle.net/2381/38524
Embargo on file until: 7-May-2017
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2016, Nature Publishing Group. Deposited with reference to the publisher’s open access archiving policy.
Appears in Collections:Published Articles, Dept. of Molecular and Cell Biology

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SupplementaryResults.pdfPost-review (final submitted author manuscript)12.83 MBAdobe PDFView/Open


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