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Title: Quantitative analysis of methyl and propyl parabens in neonatal DBS using LC-MS/MS.
Authors: Yakkundi, S.
Mulla, Hussain
Pandya, Hitesh
Turner, M. A.
McElnay, J.
First Published: 23-May-2016
Publisher: Future Science
Citation: Bioanalysis, 2016, 8 (11), pp. 1173-1182
Abstract: AIM: Excipients are used to overcome the chemical, physical and microbiological challenges posed by developing formulated medicines. Both methyl and propyl paraben are commonly used in pediatric liquid formulations. There is no data on systemic exposure to parabens in neonates. The European Study of Neonatal Exposure to Excipients project has investigated this. Results & methodology: DBS sampling was used to collect opportunistic blood samples. Parabens were extracted from the DBS and analyzed using a validated LC-MS/MS assay. DISCUSSION & CONCLUSION: The above assay was applied to analyze neonatal DBS samples. The blood concentrations of parabens in neonates confirm systemic exposure to parabens following administration of routine medicines.
DOI Link: 10.4155/bio-2016-0029
ISSN: 1757-6180
eISSN: 1757-6199
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: This article is distributed under the terms of the Creative Commons Attribution License 4.0 which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. To view a copy of the license, visit
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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