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Title: No Evidence for Association of β-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS
Authors: Abujaber, Razan
Shea, P.
McLaren, P.
Lakhi, S.
Gilmour, J.
Allen, S.
Fellay, J.
Hollox, Edward
IAVI Africa HIV prevention Partnership
Swiss HIV Cohort Study
First Published: 13-Jan-2017
Publisher: Wiley for University College London
Citation: Annals of Human Genetics, 2017, 81, pp. 27–34.
Abstract: Common single nucleotide variation in the host accounts for 25% of the variability in the plasma levels of HIV during the clinical latency stage (viral load setpoint). However, the role of rare variants and copy number variants remains relatively unexplored. Previous work has suggested copy number variation of a cluster of β-defensin genes affects HIV load in treatment-naïve sub-Saharan Africans and rate of response to anti-retroviral treatment. Here we analyse a total of 1827 individuals from two cohorts of HIV-infected individuals from Europe and sub-Saharan Africa to investigate the role of β-defensin copy number variation on HIV load at setpoint. We find no evidence of for association of copy number with viral load. We also compare distribution of β-defensin copy number between European cases and controls and find no differences, arguing against a role of β-defensin copy number in HIV acquisition. Taken together, our data argues against an effect of copy number variation of the β-defensin region in the spontaneous control of HIV infection.
DOI Link: 10.1111/ahg.12182
ISSN: 0003-4800
eISSN: 1469-1809
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2017, Wiley for University College London. Deposited with reference to the publisher’s open access archiving policy.
Description: Author confirms PDF is post-print.
The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Genetics

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