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Title: Induction treatment of previously undiagnosed ANCA-associated vasculitis in a renal transplant patient with Rituximab.
Authors: Graham-Brown, M. P.
Aljayyousi, R.
Baines, R. J.
Burton, J. O.
Brunskill, N. J.
Furness, P.
Topham, P.
First Published: Oct-2016
Publisher: Oxford University Press (OUP)
Citation: Oxford Medical Case Reports, 2016;10, 248–251
Abstract: We report the case of a 40-year-old female transplant patient with undiagnosed ANCA-associated vasculitis (AAV) and renal allograft dysfunction who achieved disease remission with restoration of transplant function following induction therapy with rituximab. There are currently no trial data looking at the use of rituximab for induction of remission of renal transplant patients with AAV. Although recurrence of AAV following renal transplantation is rare, such patients have invariably had multiple previous exposures to induction and maintenance immunosuppressive regimens, often limiting treatment options post-transplantation. In this case, rituximab was well tolerated with no side effects, and was successful in salvaging transplant function. Optimal treatment regimens for relapsed AAV in the transplant population are not known, and clinical trials are needed to evaluate the efficacy and safety of rituximab at inducing and maintaining disease remission in relapsed AAV following transplantation.
DOI Link: 10.1093/omcr/omw073
eISSN: 2053-8855
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: © The Author 2016. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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