Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/38685
Title: "Lone" Atrial Fibrillation Is Associated With Impaired Left Ventricular Energetics That Persist Despite Successful Catheter Ablation.
Authors: Wijesurendra, R. S.
Liu, A.
Eichhorn, C.
Ariga, R.
Levelt, E.
Clarke, W. T.
Rodgers, C. T.
Karamitsos, T. D.
Bashir, Y.
Ginks, M.
Rajappan, K.
Betts, T.
Ferreira, V. M.
Neubauer, S.
Casadei, B.
First Published: 14-Sep-2016
Publisher: American Heart Association, Lippincott, Williams & Wilkins
Citation: Circulation. 2016;134:1068–1081.
Abstract: BACKGROUND: -"Lone" atrial fibrillation (AF) may reflect a subclinical cardiomyopathy that persists after sinus rhythm (SR) restoration, providing a substrate for AF recurrence. To test this hypothesis, we investigated the effect of restoring SR by catheter ablation on left ventricular (LV) function and energetics in patients with AF but no significant comorbidities. METHODS: -Fifty-three patients with symptomatic paroxysmal or persistent AF and without significant valvular disease, uncontrolled hypertension, coronary artery disease, uncontrolled thyroid disease, systemic inflammatory disease, or diabetes (i.e. "lone" AF) undergoing ablation and 25 matched controls in SR were investigated. Magnetic resonance imaging quantified LV ejection fraction (LVEF), peak systolic circumferential strain (PSCS), and left atrial volumes and function, while Phosphorus-31 MR spectroscopy evaluated ventricular energetics (ratio of phosphocreatine-to-adenosine triphosphate [PCr/ATP]). AF burden was determined pre- and post-ablation by 7-day Holter monitoring; intermittent ECG event monitoring was also undertaken after ablation to investigate for asymptomatic AF recurrence. RESULTS: -Before ablation, LV function and energetics were both significantly impaired in patients compared to controls (respectively: LVEF 61% [IQR 52-65%] versus 71% [IQR 69-73%], p<0.001; PSCS -15% [IQR -11 to -18%] versus -18% [-17 to -19%], p=0.002; PCr/ATP 1.81±0.35 versus 2.05±0.29, p=0.004). As expected, patients also had dilated and impaired left atria compared to controls (all p<0.001). Early after ablation (1 to 4 days), LVEF and PSCS improved in patients recovering SR from AF (respectively: LVEF +7.0±10%, p=0.005; PSCS -3.5±4.3%, p=0.001) but were unchanged in those in SR during both assessments (both p=ns). At 6-9 months post-ablation, AF burden reduced significantly (from 54% [IQR 1.5%-100%] to 0% [IQR 0%-0.1%], p<0.001). However, LVEF and PSCS did not improve further (both p=ns) and remained lower than in controls (p<0.001 and p=0.003, respectively). Similarly, there was no significant improvement in atrial function from pre-ablation (p=ns), and this also remained lower than in controls (p<0.001). PCr/ATP was unaffected by heart rhythm during assessment and AF burden before ablation (both p=ns). It was unchanged post-ablation (p=0.57), remaining lower than in controls irrespective of both recovery of SR and freedom from recurrent AF (p=0.006 and p=0.002, respectively). CONCLUSIONS: -"Lone" AF patients have impaired myocardial energetics and subtle LV dysfunction, which do not normalise after ablation. These findings suggest that AF may be the consequence (rather than the cause) of an occult cardiomyopathy, which persists despite a significant reduction in AF burden following ablation.
DOI Link: 10.1161/CIRCULATIONAHA.116.022931
ISSN: 0009-7322
eISSN: 1524-4539
Links: http://circ.ahajournals.org/content/134/15/1068
http://hdl.handle.net/2381/38685
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: © 2016 The Authors. Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Description: The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/doi:10.1161/CIRCULATIONAHA.116.022931/-/DC1.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

Files in This Item:
File Description SizeFormat 
1068.full.pdfPublished (publisher PDF)1.91 MBAdobe PDFView/Open


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.