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Title: The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children
Authors: Vardavas, C. I.
Hohmann, C.
Patelarou, E.
Martinez, D.
Henderson, A. J.
Granell, R.
Sunyer, J.
Torrent, M.
Fantini, M. P.
Gori, D.
Annesi-Maesano, I.
Slama, R.
Duijts, L.
de Jongste, J. C.
Aurrekoetxea, J. J.
Basterrechea, M.
Morales, E.
Ballester, F.
Murcia, M.
Thijs, C.
Mommers, M.
Kuehni, C. E.
Gaillard, E. A.
Tischer, C.
Heinrich, J.
Pizzi, C.
Zugna, D.
Gehring, U.
Wijga, A.
Chatzi, L.
Vassilaki, M.
Bergstrom, A.
Eller, E.
Lau, S.
Keil, T.
Nieuwenhuijsen, M.
Kogevinas, M.
First Published: 30-Jun-2016
Publisher: European Respiratory Society: ERJ, Wiley
Citation: European Respiratory Journal, 2016, 48 (1), pp. 115-124 (10)
Abstract: Maternal smoking during pregnancy increases childhood asthma risk, but health effects in children of nonsmoking mothers passively exposed to tobacco smoke during pregnancy are unclear. We examined the association of maternal passive smoking during pregnancy and wheeze in children aged ≤2 years. Individual data of 27 993 mother–child pairs from 15 European birth cohorts were combined in pooled analyses taking into consideration potential confounders. Children with maternal exposure to passive smoking during pregnancy and no other smoking exposure were more likely to develop wheeze up to the age of 2 years (OR 1.11, 95% CI 1.03–1.20) compared with unexposed children. Risk of wheeze was further increased by children's postnatal passive smoke exposure in addition to their mothers' passive exposure during pregnancy (OR 1.29, 95% CI 1.19–1.40) and highest in children with both sources of passive exposure and mothers who smoked actively during pregnancy (OR 1.73, 95% CI 1.59–1.88). Risk of wheeze associated with tobacco smoke exposure was higher in children with an allergic versus nonallergic family history. Maternal passive smoking exposure during pregnancy is an independent risk factor for wheeze in children up to the age of 2 years. Pregnant females should avoid active and passive exposure to tobacco smoke for the benefit of their children's health.
DOI Link: 10.1183/13993003.01016-2015
ISSN: 0903-1936
eISSN: 1399-3003
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Creative Commons “Attribution Non-Commercial No Derivatives” licence CC BY-NC-ND, further details of which can be found via the following link: Archived with reference to SHERPA/RoMEO and publisher website.
Description: 18 month embargo
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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