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Title: Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits.
Authors: Dautan, Daniel
Souza, A. S.
Huerta-Ocampo, I.
Valencia, M.
Assous, M.
Witten, I. B.
Deisseroth, K.
Tepper, J. M.
Bolam, J. P.
Gerdjikov, Todor V.
Mena-Segovia, J.
First Published: 27-Jun-2016
Publisher: Nature Publishing Group
Citation: Nature Neuroscience, 2016, 19 (8), pp. 1025-1033
Abstract: Dopamine neurons in the ventral tegmental area (VTA) receive cholinergic innervation from brainstem structures that are associated with either movement or reward. Whereas cholinergic neurons of the pedunculopontine nucleus (PPN) carry an associative/motor signal, those of the laterodorsal tegmental nucleus (LDT) convey limbic information. We used optogenetics and in vivo juxtacellular recording and labeling to examine the influence of brainstem cholinergic innervation of distinct neuronal subpopulations in the VTA. We found that LDT cholinergic axons selectively enhanced the bursting activity of mesolimbic dopamine neurons that were excited by aversive stimulation. In contrast, PPN cholinergic axons activated and changed the discharge properties of VTA neurons that were integrated in distinct functional circuits and were inhibited by aversive stimulation. Although both structures conveyed a reinforcing signal, they had opposite roles in locomotion. Our results demonstrate that two modes of cholinergic transmission operate in the VTA and segregate the neurons involved in different reward circuits.
DOI Link: 10.1038/nn.4335
ISSN: 1097-6256
eISSN: 1546-1726
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Creative Commons “Attribution Non-Commercial No Derivatives” licence CC BY-NC-ND, further details of which can be found via the following link: Archived with reference to SHERPA/RoMEO and publisher website.
Description: The data that support the findings of this study and the custom Matlab code are available from corresponding author on request. 6 Month embargo for full text.
Appears in Collections:Published Articles, Dept. of Neuroscience, Psychology and Behaviour

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