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Title: Long-term coding of personal and universal associations underlying the memory web in the human brain.
Authors: De Falco, Emanuela
Ison, Matias J.
Fried, I
Quian Quiroga, Rodrigo
First Published: 15-Nov-2016
Publisher: Nature Publishing Group
Citation: Nature Communications, 2016, 7:13408
Abstract: Neurons in the medial temporal lobe (MTL), a critical area for declarative memory, have been shown to change their tuning in associative learning tasks. Yet, it is unclear how durable these neuronal representations are and if they outlast the execution of the task. To address this issue, we studied the responses of MTL neurons in neurosurgical patients to known concepts (people and places). Using association scores provided by the patients and a web-based metric, here we show that whenever MTL neurons respond to more than one concept, these concepts are typically related. Furthermore, the degree of association between concepts could be successfully predicted based on the neurons' response patterns. These results provide evidence for a long-term involvement of MTL neurons in the representation of durable associations, a hallmark of human declarative memory.
DOI Link: 10.1038/ncomms13408
eISSN: 2041-1723
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Description: The data that support the findings of this study are available from the corresponding author on reasonable request. Supplementary Information accompanies this paper at
Appears in Collections:Published Articles, Dept. of Engineering

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