Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/38900
Title: Human activated macrophages and hypoxia: a comprehensive review of the literature
Authors: Sotoodehnejadnematalahi, F.
Burke, Bernard
First Published: Nov-2014
Publisher: Mashhad University of Medical Sciences
Citation: Iranian Journal of Basic Medical Sciences, 2014; 17:820-830.
Abstract: Macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods. Up to date, different studies have shown that a number of transcription factors are activated by hypoxia which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro-metastatic genes. On the other hand, macrophages respond to hypoxia by up-regulating several genes which are chief factors in angiogenesis and tumorigenesis. Therefore, in this review article we focus mainly on the role of macrophages during inflammation and discuss their response to hypoxia by regulating a diverse array of transcription factors. We also review the existing literatures on hypoxia and its cellular and molecular mechanism which mediates macrophages activation.
DOI Link: 10.22038/ijbms.2014.3708
ISSN: 2008-3866
eISSN: 2008-3874
Links: http://ijbms.mums.ac.ir/article_3708_0.html
http://hdl.handle.net/2381/38900
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Archived with reference to SHERPA/RoMEO and publisher website. http://ijbms.mums.ac.ir/journal/authors.note
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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