Please use this identifier to cite or link to this item:
|Title:||Novel plasma and imaging biomarkers in heart failure with preserved ejection fraction|
Squire, Iain B.
Ng, Leong L.
McCann, Gerry P.
|Citation:||International Journal of Cardiology: Heart and Vasculature , 2015, 9, pp. 55-62|
|Abstract:||Existing diagnostic guidelines for heart failure with preserved ejection fraction (. HFPEF) primarily comprise natriuretic peptides and echocardiographic assessment, highlighting the role of diastolic dysfunction. However, recent discoveries of novel plasma markers implicated in pathophysiology of heart failure and technological advances in imaging provide additional biomarkers which are potentially applicable to HFPEF. The evidence base for plasma extra-cellular matrix (ECM) peptides, galectin-3, ST2, GDF-15 and pentraxin-3 is reviewed. Furthermore, the capabilities of novel imaging techniques to assess existing parameters (e.g. left ventricular ejection fraction, systolic & diastolic function, chamber size) and additional derangements of the ECM, myocardial mechanics and ischaemia evaluation are addressed.|
|Rights:||© 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).|
|Description:||Supplementary data to this article can be found online at http://dx.doi.org/10.1016/j.ijcha.2015.07.004.|
|Appears in Collections:||Published Articles, Dept. of Cardiovascular Sciences|
Files in This Item:
|1-s2.0-S2352906715300166-main.pdf||Published (publisher PDF)||681.05 kB||Adobe PDF||View/Open|
Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.