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Title: Novel plasma and imaging biomarkers in heart failure with preserved ejection fraction
Authors: Kanagala, Prathap
Squire, Iain B.
Ng, Leong L.
McCann, Gerry P.
First Published: 30-Jul-2015
Publisher: Elsevier
Citation: International Journal of Cardiology: Heart and Vasculature , 2015, 9, pp. 55-62
Abstract: Existing diagnostic guidelines for heart failure with preserved ejection fraction (. HFPEF) primarily comprise natriuretic peptides and echocardiographic assessment, highlighting the role of diastolic dysfunction. However, recent discoveries of novel plasma markers implicated in pathophysiology of heart failure and technological advances in imaging provide additional biomarkers which are potentially applicable to HFPEF. The evidence base for plasma extra-cellular matrix (ECM) peptides, galectin-3, ST2, GDF-15 and pentraxin-3 is reviewed. Furthermore, the capabilities of novel imaging techniques to assess existing parameters (e.g. left ventricular ejection fraction, systolic & diastolic function, chamber size) and additional derangements of the ECM, myocardial mechanics and ischaemia evaluation are addressed.
DOI Link: 10.1016/j.ijcha.2015.07.004
ISSN: 2352-9067
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: © 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (
Description: Supplementary data to this article can be found online at
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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