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Title: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Other Titles: Discovery and validation of 107 blood pressure loci from UK Biobank offers novel biological insights into cardiovascular risk
Authors: Taylor, L. V.
Warren, H. R.
Evangelou, E.
Cabrera, C. P.
Gao, H.
Ren, M.
Mifsud, B.
Ntalla, I.
Surendran, P.
Liu, C.
Cook, J. P.
Kraja, A.
Drenos, F.
Loh, M.
Verweij, N.
Marten, J.
Karaman, I.
Lepe, M. P. S.
O’Reilly, P.
Knight, J.
Snieder, H.
Kato, N.
He, J.
Tai, E. S.
Said, A. M.
Porteous, D.
Alver, M.
Poulter, N.
Farrall, M.
Gansevoort, R. T.
Padmanabhan, S.
Mägi, R.
Stanton, A.
Connell, J.
Bakker, S. J. L.
Metspalu, A.
Shields, D.
Thom, S.
Brown, M.
Sever, P.
Esko, T.
Hayward, C.
van der Harst, P.
Saleheen, D.
Chowdhury, R.
Chambers, J. C.
Chasman, D. I.
Chakravarti, A.
Newton-Cheh, C.
Lindgren, C. M.
Levy, D.
Kooner, J. S.
Keavney, B.
Tomaszewski, M.
Samani, Nilesh J.
Howson, J. M. M.
Tobin, Martin D.
Munroe, P. B.
Ehret, G. B.
Wain, Louise V.
Barnes, M. R.
Tzoulaki, I.
Caulfield, M. J.
Elliott, P.
First Published: 30-Jan-2017
Publisher: Nature Publishing Group
Citation: Nature Genetics, 2017, 49(3), pp.403-415.
Abstract: Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, leading to discovery and validation of 107 novel loci. We also identify new independent variants at 11 previously reported blood pressure loci. Combined with results from a range of in-silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure raising variants on future cardiovascular disease risk.
DOI Link: 10.1038/ng.3768
ISSN: 1061-4036
eISSN: 1546-1718
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2017, Nature Publishing Group. Deposited with reference to the publisher’s open access archiving policy. Archived with reference to SHERPA/RoMEO and publisher website.
Description: The file associated with this record is under embargo until 6 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Health Sciences

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