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Title: Detection of somatic changes in human cancer DNA by DNA fingerprint analysis
Authors: Thein, S. L.
Jeffreys, A. J.
Gooi, H. C.
Cotter, F.
Flint, J.
O'Connor, N. T. J.
Weatherall, D. J .
Wainscoat, J. S .
First Published: Apr-1987
Publisher: Cancer Research UK, Nature Publishing Group
Citation: British Journal of Cancer, (1987) 55, 353–356.
Abstract: Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 cases. The changes included alterations in the relative intensities of hybridising DNA fragments, and, in three cases of cancers of gastrointestinal origin, the appearance of novel minisatellite fragments not seen in the corresponding constitutional DNA. The results of this preliminary study suggests that DNA fingerprint analysis provides a useful technique for identifying somatic changes in cancers.
DOI Link: 10.1038/bjc.1987.71
ISSN: 0007-0920
eISSN: 1532-1827
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Creative Commons “Attribution Non-Commercial No Derivatives” licence CC BY-NC-ND, further details of which can be found via the following link: Archived with reference to SHERPA/RoMEO and publisher website.
Appears in Collections:Published Articles, Dept. of Genetics

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